The diagnosis of anthracycline-induced cardiac damage and heart failure
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2009, Vol 63, Issue
Abstract
Routine examinations during chemotherapy containing anthracyclines evaluate heart function before treatment and monitor cardiotoxic effects during and after therapy. A number of methods are useful in cardiac assessment, including electrocardiography, radiology techniques (RTG, CT, MRI, PET-CT, PET-MRI), echocardiography, radioisotope imaging techniques (scyntygraphy, MUGA, PET), and ultra-structure evaluation in biopsy samples. Nevertheless, there is a continuous need for new methods to predict future damage at the initial stages of cardiac changes. In recent years the therapeutic usefulness of biochemical blood parameters in anthracycline-treated patients has been assessed. The levels of cardiac troponines (cTnI, cTnT), natriuretic peptides (ANP, BNP), and endothelin 1 have been included in the studies. Heart-type fatty acid binding protein (H-FABP) is another promising factor showing cardiomyocytic impairment. However, the clinical use of biochemical parameters in diagnosing anthracycline-related cardiotoxicity is still a controversial issue.
Authors and Affiliations
Jarosław Dudka, Franciszek Burdan, Agnieszka Korga, Katarzyna Dyndor, Iwona Syroka, Justyna Zięba, Dorota Lewkowicz
Keywords
Related Articles
- EP ID EP66331
- DOI -
- Views 187
- Downloads 0
The participation of outer membrane proteins in the bacterial sensitivity to nanosilver
The presented study is to analyze the participation of outer membrane proteins of Gram- negative bacteria in sensitivity to silver nanomaterials. The mechanism of interaction of silver with the bacterial cell is best des...
The effect of NaCl on the level of reduced sulfur compounds in rat liver. Implications for blood pressure increase
Background: It is commonly known that excessive salt intake is a risk factor of hypertension. Currently, there is an increasing interest in reduced reactive sulfur species (RSS), mainly H2S and sulfane sulfur (SS) as new...
Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS
The early diagnosis of the nephrotoxic effect of xenobiotics and drugs is still an unsolved problem. Recent studies suggest a correlation between the nephrotoxic activity of xenobiotics and increased concentration of ami...
Blood groups – minuses and pluses. Do the blood group antigens protect us from infectious diseases?
Human blood can be divided into groups, which is a method of blood classification based on the presence or absence of inherited erythrocyte surface antigens that can elicit immune response. According to the International...
Relaxin-3 and relaxin family peptide receptors – from structure to functions of a newly discovered mammalian brain system
Relaxin-3, a member of the relaxin peptide family, was discovered in 2001 as a homologue of relaxin – a well-known reproductive hormone. However, it is the brain which turned out to be a major expression site of this new...