The Difference Between Physalin Standardized Extract from Pysalis Angulata. L and Control on Pancreatic Function of Sprague Dawley Rat Induced by Streptozotocin-Nicotinamide
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 4
Abstract
Abstract: Diabetes mellitus (DM) is a metabolic disorder of carbohydrate, fat, and protein characterized by chronic hyperglycemia conditions. Oxidative stress due to hyperglycemia in patients with diabetes may fasten the process of pancreatic tissue damage. Physalis angulata L or Ciplukan herb is one of Indonesian medicinal plants that has been used traditionally and empirically proven as an antidiabetic. Objective the study was determine whether there is a difference between physalin standardized extract from Physalis angulata L and control on pancreatic function of Sprague Dawley rat induced by Streptrozotocin-Nicotinamide. The study was true experimental research design with a post-test only control group design. The subjects of this study were 32 male Sprague Dawley rat induced by Streptozotocin and Nicotinamide. The extract was given a dose of 20 mg / kg for 21 days. At the end of the study, pancreas organs were taken for histological preparations. There were continued by observed of the diameter of Langerhans islets. Normality test data Kolmogorov Smirnof was to determine the differences analysed by t-test. There was a significant difference between the diameter of the islets of Langerhans treatment and control group (p = 0.001). The provision of physalin standardized extract from Physalis angulata L at a dose of 20 mg / kg BW can repair the size of the islets of Langerhans. The treatment can prevent oxidative stress and are able to maintain cell function of pancreas. Keywords: Diabetes Mellitus, Physalis angulata L (Ciplukan herb), pancreatic function.
Authors and Affiliations
Yeny Sulistyowati, Sri Kadarsih Soedjono, Mustofa . , Budi Mulyono
Keywords
Related Articles
- EP ID EP375302
- DOI -
- Views 94
- Downloads 0
One Week Post Natal Changes in Neonatal Lipid Profile Values and Its Association with Gestational Age: A Prospective Study in North India
Adult serum lipid disorders have their root in childhood. Most of the past studies have measured lipid profiles at birth and the next measure earliest at 6 months after birth. The aim of this study was to estimate the ne...
Minimally invasive technique for recurrence of Aneurysmal bone cyst following extensive operative procedure- A case report
A 3 year old girl diagnosed with pathological fracture of the lower end of right tibia due to Aneurysmal Bone Cyst (histopathological and radiological diagnosis) who underwent curettage of the lytic lesion and filling of...
Investigating Hepatitis B Immunity In Children with with newly diagnosed Acute Lymphoblastic Leukemia presenting at a Tertiary Cancer Care Centre
Hepatitis B is a dreaded infectious disease and one of the major global public health problems .In India, the prevalence of hepatitis B surface antigen (HBsAg) among the general population ranges from 2% to 8%, placing I...
Outcome of Proximal Femoral Nailing in unstable trochanteric fractures
Abstract: The incidence of intertrochanteric fractures of the femur has been increasing in the recent years and the treatment of these fractures pose a challenge, due to their unstable nature. Surgical management of thes...
Acute Vision Loss: Aetiology, Clinical Profile and Prognosis
Vision is one of the essential and important senses of human body. Loss of vision leaves a significant handicap in a person and so it compels the treating physician to analyse and find the potentially treatable cause for...