The Difference of Kidney, Heart and Blood Function on Cervical Cancer Patients with Chemotherapy, Bleomycin, Oncovin®, Mitomycin and Carboplatin (Case Study in Sanglah General Hospital, Denpasar in 2015)
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2016, Vol 5, Issue 4
Abstract
Oncovin® bleomycin mitomycin-carboplatin (BOM-carboplatin) regimen as chemotherapy is inseparable from the side effects it can caused which is toxicity to organs including the kidneys, liver, and blood where the toxicity in the kidneys can be indicated by the parameter of Serum Creatinine and Blood Urea Nitrogen (BUN), the occurrence of toxicity in the liver can be measured by the parameters of SGOT and SGPT, and toxicity to blood function can be indicated by the value of hemoglobin, platelets, leukocytes. The absence of data on the toxic effects of chemotherapy BOM-carboplatin in patients with squamous cell cervical cancer stage IIB–IIIB in Sanglah General Hospital in Denpasar, had made this research conducted through monitoring of kidney, liver and blood function. This study is an observational case study of nine patients who were followed for three rounds of chemotherapy from February to August 2015. Data of creatinine serum, BUN, SGOT, SGPT, hemoglobin, platelets, and leukocytes were analyzed using paired t-test for the data that were normally distributed and Wilcoxon test for the data that were not normally distributed with a confidence level of 95% and was said to be significantly different when p<0.05. The results of this case study demonstrated the value of serum creatinine (p=0.530), BUN (p=0.553), SGOT (p=0.162), SGPT (p=0.054), hemoglobin (p=0.034), platelets (p=0.028), and leukocytes (p=0.011) so it could be concluded that there was a significant decrease of blood function which could be characterized by a significant decrease in the parameters of hemoglobin, platelets and leucocytes before chemotherapy I and after chemotherapy III BOM-carboplatin, so it required strict monitoring of the blood function of the patients who received chemotherapy BOM-carboplatin in Sanglah General Hospital in Denpasar.
Authors and Affiliations
Rini Noviyani, I Nyoman G. Budiana, Putu A. Indrayathi, Rasmaya Niruri, I Ketut Tunas
Keywords
Related Articles
- EP ID EP368893
- DOI 10.15416/ijcp.2016.5.4.269
- Views 107
- Downloads 0
Adherence and Quality of Life of Hypertension Patients in Gunung Jati Hospital, Cirebon, Indonesia
The treatment effectiveness of hypertension could be influenced by patients’ characteristics and patients’ adherence with medication. Besides reaching the goal of blood pressure decrease after the treatment, their qualit...
Health-Related Quality of Life of Type 2 Diabetes Mellitus Outpatients at Dr. Sardjito Hospital, Yogyakarta, Indonesia: An Insulin-Based Therapy Approach
Diabetes mellitus type 2 is a lifelong disease which needs an intensive therapy to maintain stable blood sugar levels. Insulin has been proven as an effective treatment modality for type 2 diabetes mellitus patient. The...
Patient Care Indicator: Degenerative-Nondegenerative Patients and Compounded-Non-Compounded Prescription in One of Community Pharmacy in Bandung
Pharmacy is one of facilities for pharmacist to do a pharmaceutical care. It has been reported that 50% of patients failed to receive a treatment properly because of error in prescription and dispensing practices. Pharma...
The Impact of Performance Appraisal and Compensation to Performance of Pharmacy Technical Personnel Non-Civil Servants at Hasan Sadikin Hospital
Performance is the result of the quality and quantity of work achieved by an employee. This study aimed to determine the effect of performance appraisal and compensation to performance of Pharmacy Technical Personnel Non...
Antibiotic Usage Profile after Antibiotic Stewardship Program Implementation in Intensive Care Unit of dr. Ramelan Naval Hospital Surabaya
Antibiotic Stewardship Program (ASP) is mandatory to all Indonesian hospitals, in accordance to the 2015 Minister of Health Decree No. 8. Dr. Ramelan Naval Hospital Surabaya is one among the many hospitals in Indonesia t...