The effect of 17α-Hydroxyprogestrone Caproate on prevention of preterm labor in high-risk pregnant women: a clinical trial study
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 11
Abstract
Preterm labor is defined as birth before 37th week of pregnancy. Despite of progressive improvement in gynecological care, the prevalence of preterm labor is growing. The aim of this study was to investigate the effect of 17α-Hydroxyprogestrone Caproate on prevention of preterm labor in high-risk pregnant women. This doubleblinded clinical trial study was conducted on 100 pregnant women who admitted to Besat hospital, Sananadj, Iran during 2013-2014. Women were block randomized and divided in two intervention (n=50) and control (n=50) groups. The intervention group was injected 250 mg 17α-Hydroxyprogestrone Caproate intramuscularly during 24th until 34th week on a weekly basis and placebo was given to control group. The results showed that 11 women (22%) with preterm labor on less than 37 week and 39 (78%) on more than 37 week, however, in placebo group these figures were 29 (58%) and 21 (42%), respectively. This finding showed that 17α-Hydroxyprogestrone Caproate had preventive effect on preterm labor in intervention group. The logistic regression also showed that there was a significant difference between two intervention and control groups (p=0.001). It seems that 17α- Hydroxyprogestrone Caproate had preventive effect on preterm labor.
Authors and Affiliations
Shole Shahgheibi| Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Nasrin Soofizadeh| Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Aidin Mojtahedzadeh| Assistant Professor, Department of Pathology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Masomeh Rezaei| Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Fariba Seydoshohadaei| Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Ghobad Moradi| Assistant Professor, Department of Epidemiology Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Nazli Hamrah| Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of medical science, Sanandaj, Iran, Corresponding Email: hamrahnazli@gmail.com
Keywords
Related Articles
- EP ID EP12142
- DOI -
- Views 302
- Downloads 12
The Effectiveness of Ambon Banana Peel Extract (Musa sapientum) as Atherosclerosis Prevention through Inhibition of NF-κβ and Increased eNOS Expression in Atherogenic Rat Model
Atherosclerosis is a disease in which plaque builds up inside the arteries. During the early phase, endothelial nitric oxide nitrate (eNOS) decrease and nuclear factor kappa beta (NF-κβ) increase. Ambon banana peel co...
The effect of covering head on the hypocalcemia caused by phototherapy in the icteric preterm infants in the Vali-e-Asr hospital in 2015; A Randomized Controlled Trial
There are several methods to reduce serum bilirubin in neonatal jaundice that the most common of them is phototherapy and this method will cause some side effects which one of them is hypocalcemia that is occurred due t...
The level of professional socialization of nursing students of Ilam University of Medical Sciences in 2016
Socialization is a basic and fundamental concept in nursing. There is a great need to evaluate professional socialization of nursing students. The aim of study was determining the factors affecting on the level of profe...
A study of the clinical profile and outcome of spina bifida
Neural tube defects (NTDs) are a group of congenital anomalies characterized by defects in dorsal midline structures, including neural tissue, dura, muscle, bone and/or skin. The clinical presentations and the follow-up...
Effects of aerobic training on FBS, HbA1C, Fructosamine and plasma lipid profile in male with type 2 diabetes
Regular exercise represents an effective strategy to prevent and treat type 2 Diabetes.The present study examined the effects of aerobic exercise on glycemic control and serum lipid profile in men with type 2 diabetes.2...