The Effect of Aerobic Training and Consumption of L-carnitine Supplements on Gen Expression of HMG-CoA Reductase in the Liver of Male Wistar Rats Toxicated by Boldenone
Journal Title: International Journal of Applied Exercise Physiology - Year 2018, Vol 7, Issue 2
Abstract
The aim of this study was to investigate the effect of aerobic training and consumption of L-carnitine supplements on HMG-CoA reductase and LDL receptor in the liver of male Wistar rats toxicated by Boldenone. A number of 30 male Wistar rats aged 12 weeks (weighing 195±7.94g) were randomly divided into five groups: control, sham, boldenone (5mg/kg), L-carnitine, aerobic training- L-carnitine. The endurance moderate intensity training program (55-50% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Injection was administered once a week, on an appointed day, in the quadriceps and hamstring in depth. After anesthesia, autopsy was performed and the tests were isolated. HMG-CoA reductase and LDL receptor expression in the samples were measured by Real Time PCR and the quantification of gene expression levels using the formula 2-ΔΔct were analyzed by One-way ANOVA and post hoc Scheffe was significant at P<0. 05. The results showed that aerobic training and supplementation with L-carnitine had a significant effect on HMG CoA reductase and LDL-R in the liver of male Wistar rats toxicated by boldenone (P=0/000). The results also showed that the expression of HMG-CoA reductase changes in the liver of male Wistar rats in Group training - L-carnitine significantly lower than the control group (P=0/000). Changes in the expression of LDL-R in groups training - L-carnitine and L-carnitine increased significantly compared to control group (P=0/000). According to the findings, supplementation with L-carnitine with regular aerobic training modulates the biosynthesis of cholesterol in liver tissue.
Authors and Affiliations
Behnam Bagherzadeh Rahmani
Keywords
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- EP ID EP570125
- DOI 10.22631/ijaep.v7i2.291
- Views 84
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