The Effect of Co-infection with Hepatitis C Virus on Incidence of Anaemia, Liver Transaminases and Immunological Markers among HIV Patients on HAART in South West (Osun State) Nigeria
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 6, Issue 8
Abstract
Introduction: It is becoming clear that a major complication of HIV patients on HAART is co-infection with hepatitis C and its attendant sequalae such as liver cirrhosis and carcinoma. The aim is to determine the prevalence of anaemia, transaminitis in these co-infected patients. Materials and Methods: Three groups of patients were studied. There were a total of 44 male and 106 females included in the study. No children were among. Those co-infected with both HIV and HCV (group I), HIV only (group II) and negative for both viruses (Group III). Each group consists of 50 patients each. HIV status was determined utilizing determine and Unigold to detect HIV antibodies. HCV was determined by detecting the anti-HCV antibody (IgG) using third generation ELISA kit from DIA.PRO, Italy. The haematological indices were determined using the Sysmex haematology analyser. Liver transaminases were determined from the sera of the participants using Randox kits and absolute CD4 positive lymphocyte cells were determined using Partec cyflow (SL Green). The results were statistically analysed. Results: No case of anaemia was detected. CD4 counts in group I patients (HIV /HCV positive) and group II patients were clearly reduced. The CD 4 counts were markedly reduced when compared to the controls (group III) P<0.005. The liver enzymes were markedly raised in co-infected patients. Conclusion: The major observations in our group of co-infected patients was marked transaminitis and reduced CD 4 counts in co-infected patients. It is necessary to determine HCV genotypes to explain why our patients have not presented with increased cirrhosis and hepatic carcinoma.
Authors and Affiliations
V. O. Mabayoje, M. A. Muhibi, C. A. Akinleye, R. A. Akindele
Keywords
Related Articles
- EP ID EP347308
- DOI 10.9734/BJMMR/2015/15142
- Views 75
- Downloads 0
Assessment of Hospital Physicians' Knowledge, Awareness, Attitude and Practice of Reporting Adverse Drug Reactions in Jeddah, Saudi Arabia
Background: Adverse drug reactions (ADRs) are an important cause of morbidity and mortality around the world. Spontaneous reporting of ADRs is considered an essential component of successful pharmacovigilance (PV). Physi...
Critical Care Nurses’ Attitudes about Influences of Technology on Nursing Care
Aims: This paper begins with developing a quantitative instrument to examine the opinions of critical care nurses’ regarding the influences of technology on nursing practice. Study Design and Methodology: After reviewing...
Monocyte Chemoattractant Protien-1 (MCP-1) and Atherosclerosis in End Stage Renal Disease Patients
Background: Emerging evidences suggest that inflammation is involved in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein-1 (MCP-1) has a central role in atherogenesis. The study was performed...
Phenytoin Induced Changes in Glucose and Lipid Metabolism is Related to Increased Urate Synthesis
Aim: The study was to investigate the relationship of phenytoin-associated hyperuricaemia with the hyperglycaemia and dyslipidaemia caused by phenytoin administration. Methods: Forty-two albino Wistar rats were randomly...
Salivary α-amylase Activity and s-IgA Levels Could be Taken as a Measure of Physiological Stress in Wheelchair-dependent Persons with Physical Disabilities and Without Disability Middle-aged Persons
Aims: The s-IgA/total protein ratio and α-amylase activity in saliva have been used as indexes of stress because they change according to the physiological stress. Using both indexes, this study aimed to compare the circ...