The effect of mexidol on certain blood counts in experimental lung emphysema
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 2
Abstract
Objective — to study the effect of succinate containing mexidol on catalase activity and sorption capacity of erythrocytes in experimental pulmonary emphysema. Materials and methods. Studies were performed on 64 mature, white rats weighing 180—200 g. The model of papainic emphysema in animals was reproduced by a singledose intratracheal administration of papain, dissolved in 0.9 % NaCl solution at the rate of 50 mg/kg and 100 mg/kg. Mexidol was administered at a dose of 25 mg/kg intramuscularly daily within 2 and 3 weeks after administration of papain. The catalase activity and the sorption capacity of erythrocytes were determined. Results and discussion. It was found that emphysema is accompanied by inhibition of catalase activity with a significant decrease of erythrocytes sorption capacity, regardless of the dose of papain. Administration of Mexidol to animals within 2 and 3 weeks at a dose of 25 mg/kg leads to the restoration of catalase activity and increase the sorption capacity of erythrocytes. There was no complete restoration of the sorption capacity of erythrocytes in comparison with the control value. At the same time, in animals receiving mexidol, the sorption capacity was significantly higher than that of nontreated animals. Conclusions. Emphysematous process in the lungs leads to inhibition of catalase activity, accompanied by a decrease of the erythrocyte’s sorption capacity. Mexidol, administered to the animal during 2 and 3 weeks, restores catalase activity and increase sedimentation of erythrocytes.
Authors and Affiliations
V. I. Korzhov, V. N. Zhadan, B. O. Osypenko
Keywords
Related Articles
- EP ID EP294072
- DOI -
- Views 107
- Downloads 0
Dynamics of indicators of the healing of destructive changes in lung tissue in patients with different efficacy of treatment of multidrug-resistant tuberculosis
Objective — study of the dynamics of levels of connective tissue metabolism products in patients with multidrug-resistant tuberculosis (MDR-TB). Materials and methods. 84 patients with MDR-TB of the lungs who had a lung...
Application of collapsotherapeutic methods in complex treatment of patients with disorder chemoresistant pulmonary tuberculosis
Objective — to determine the effectiveness of using collapsotherapeutic methods in the complex treatment of patients with destructive tuberculosis of the lungs. Materials and methods. The analysis of the results of trea...
Study of cell death kinds and stages of leukocytes apoptosis in pulmonary tuberculosis patient during antimycobacterial therapy
Objective — to evaluate the condition of cytoplasmic membranes of leukocytes and to study their viability, to determine the varieties and stages of cell death of leukocytes in patients with pulmonary tuberculosis (TB) wi...
Experience of selection, indication and identication of non-tuberculous mycobacteria, got during I National research on study of distribution of drugresistant of tuberculosis in Ukraine
Objective — a study of presence of non-tuberculosis mycobacteriumin a circulatory mycobacterial population among patients by a white plague in Ukraine, finding out of etiologic role of non-tuberculosis mycobacterium, the...
Algorithm of use short 12 month regimens for the linezolid based for patients with multidrug-resistant tuberculosis: first encouraging results
Objective — to formulate clear algorithms for use of short 12 month regimens based on linezolid, with differentiation indications depending on the resistance profile of the MBT (MDR, preXDR, risk MDR), develop clear incl...