The effect of mexidol on certain blood counts in experimental lung emphysema
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 2
Abstract
Objective — to study the effect of succinate containing mexidol on catalase activity and sorption capacity of erythrocytes in experimental pulmonary emphysema. Materials and methods. Studies were performed on 64 mature, white rats weighing 180—200 g. The model of papainic emphysema in animals was reproduced by a singledose intratracheal administration of papain, dissolved in 0.9 % NaCl solution at the rate of 50 mg/kg and 100 mg/kg. Mexidol was administered at a dose of 25 mg/kg intramuscularly daily within 2 and 3 weeks after administration of papain. The catalase activity and the sorption capacity of erythrocytes were determined. Results and discussion. It was found that emphysema is accompanied by inhibition of catalase activity with a significant decrease of erythrocytes sorption capacity, regardless of the dose of papain. Administration of Mexidol to animals within 2 and 3 weeks at a dose of 25 mg/kg leads to the restoration of catalase activity and increase the sorption capacity of erythrocytes. There was no complete restoration of the sorption capacity of erythrocytes in comparison with the control value. At the same time, in animals receiving mexidol, the sorption capacity was significantly higher than that of nontreated animals. Conclusions. Emphysematous process in the lungs leads to inhibition of catalase activity, accompanied by a decrease of the erythrocyte’s sorption capacity. Mexidol, administered to the animal during 2 and 3 weeks, restores catalase activity and increase sedimentation of erythrocytes.
Authors and Affiliations
V. I. Korzhov, V. N. Zhadan, B. O. Osypenko
Keywords
Related Articles
- EP ID EP294072
- DOI -
- Views 106
- Downloads 0
Extrapulmonary tuberculosis and miliary tuberculosis in patients with TB/HIV co-infection
Abstract
Extrapulmonary tuberculosis and miliary tuberculosis in patients with TB/HIV co-infection. Part 2
-
Lung pathology and causes of death among hospitalized adult patients with HIV infection: pathological analysis
Objective — to analyze medical records, clinical and laboratory research data and autopsies of deceased HIVinfected adults in the hospital, to assess the level of coincidences and discrepancies of clinical and pathologi...
The effectiveness of immunoglobulin-G in patients with DRTB/HIV in a state of expressive immunosuppression according to hematological studies
Objective — to study hematological disorders in patients with coinfection of DR TB/HIV in a state of significant immunosuppression, and to evaluate the effectiveness of immunoglobulin therapy by IgG. Materials and meth...
Condition of the proteolytic system in patients with tuberculous pleurisy
Recently, extrapulmonary forms of tuberculosis are increasingly common, which are not related to the pulmonary system. The largest proportion of extrapulmonary forms is pleural tuberculosis. This disease in case of delay...