The effect of Policosanol on decrease of cholesterol, triglyceride and the other lipid metabolite levels in blood of Wistar rats
Journal Title: Journal of Herbal Drugs - Year 2013, Vol 3, Issue 2
Abstract
Background & Aim: Policosanol is a component from main alcohol groups with long-chain that extracted from cane sugar. In the present research, the effect of policosanol was investigated on decrease of lipid metabolite levels in blood of hypercholesterolemia rats. Experimental: A number of 32 male Wistar rats race with average weight of 250 g was divided into four groups including negative control group (n=8) that had normal diet, positive control and experimental groups I and II (n=8) with high cholesterol diet of 2% cholestroled, and respectively they received placebo and policosanol with concentrations 0.25 and 0.5 mg/day. After four weeks, following the treatment of animals and bloodletting, the biochemical traits such as cholesterol biochemical, triglyceride, and LDL-C and HDL-C factors were measured. Results & Discussion: The results showed that in experimental group (I) there was a significant decrease (p<0.05) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.05) in HDL-C compared with control group. In experimental group II, there also was a significant decrease (p<0.01) in the rate of cholesterol, LDL-C and triglyceride, and significant increase (p<0.01) in HDL-C compared with control group. Industrial and practical recommendations: Policosanol can be an effective component in decreasing the rate of cholesterol, LDL-C and triglyceride and increasing HDL-C.
Authors and Affiliations
Fatemeh Foroohi; Mansor Amraei; Hadi Zamani
Keywords
Related Articles
- EP ID EP23386
- DOI -
- Views 422
- Downloads 22
Identification and characterization of chemical composition of Rhus coriaria L. fruit from Hamadan, Western Iran
Background & Aim: Identification, characterization and detection of medicinal plants chemical composition are very important for phytochemical scientific source. Sumac is one of the medicinal plants in the world that u...
Chemical composition and antibacterial activity of essential oil from two Thymus species
Background & Aim: Staphylococcus aureus is one of the bacterial pathogens and the most important factor in hospitalized infections in human community. This bacterium is becoming resistance to chemical drugs quickly. L...
The effect of ethanolic and aqueous extracts of Berberies vulgaris on multidrug- resistant gram-negative pathogenic bacteria
Background and Aim: In recent years, due to the indiscriminate and irrational use of synthetic drugs, the resistance of pathogenic microorganisms has increased; therefore, new compounds are vitally needed. The purpose...
Rosa foetida Herrm. flowers as a future natural antibacterial agent against the main cause of skin burn wound infections, Pseudomonas aeroginosa
Background & Aim: Belongs to Rosaecea family, Rosa foetida is one the Persian native plants which has not been investigated biologically. As it is traditionally used topically as poultice to treat infectious skin burns...
Effect of ecological factors on chemical compounds of Verbascum songaricum leaves
Background & Aim: Verbascum songaricum is a perennial herbaceous belongs to the Scrophulariaceae (snapdragon) family. Current study was done to study the environmental conditions effect on phytochemical properties of Ver...