The Effect of Radiation Therapy on Hearing Loss in Patients with Head and Neck Cancer
Journal Title: International Journal of Cancer Management - Year 2018, Vol 11, Issue 4
Abstract
Background: Radiotherapy is one of the important components of head and neck cancer (HNC) treatment. This treatment method may cause a variety of side effects like oral problems, swelling, and hearing loss. Objectives: In this study, the effect of radiotherapy on hearing loss in patients with HNC was investigated. Methods: In this prospective cohort research, patients with head and neck cancer referring to the Shohadaye Tajrish Hospital during 2014 to 2015 were investigated. All of these patients were candidate for radiotherapy as the main treatment. The radiotherapy of patients was done by 3D-computer based treatment planning system, using their CT scan. In order to oncologic assessment, pre- and post-radiotherapy audiologic evaluations were done. The common toxicity criteria for the adverse events (CTCAE V4.02) of the National Cancer Institute (NCI) were used for ototoxicity. A bivariate latent variable model was used to assess the effect of received dose on the severity of hearing loss. Results: In this study, 66 patients with HNC were investigated. Among them, 46 patients (70%) were male. The mean (SD) age of patients was 45.33 (15.11). The incidence rate of hearing loss in these patients was about 18%. The result of statistical modeling showed a positive relationship between severity of HL and received dose of radiation (P < 0.001). Conclusions: In general, the findings of this study showed a direct relationship between radiation dose received by the ears and severity of hearing loss in patients with HNC. In this context, paying more attention to dose-prescription limits and standards for assessing radiation therapy associated ototoxicity are strictly recommended.
Authors and Affiliations
Samira Chaibakhsh, Farid Zayeri, Ahmad Reza Baghestani, Mohsen Bakhshandeh, Seyed Mahmood Reza Aghamiri, Akram Haji Safari
Keywords
Related Articles
- EP ID EP365706
- DOI 10.5812/ijcm.10421
- Views 79
- Downloads 0
Symptomatic Occlusion of Internal Carotid Artery Caused by Pituitary Macro Adenoma Among the Patients Without Apoplectic Signs; Case Report and Review of the Literature
Introduction Pituitary adenoma producing symptomatic carotid compression of the internal carotid artery without any apoplexy sign would be extremely rare and there was only one re...
Phytochemicals in Cancer Prevention: A Review of the Evidence
Context: Cancer generally is considered as a neoplastic disease with particular causative and etiologic factors as well as protective elements. Although it has remained difficult to treat, it is preventable. Recently, th...
Antioxidant Supplements and Breast Cancer: A Systematic Review and Meta-Analysis
Context: Breast cancer is the second most common type of cancer worldwide and the most frequent one among women. Some studies suggest a favorable role of antioxidants on breast cancer, but this is still controversial. O...
Sensitization of Radio-Resistant Lung Cancer Cells with a B Subunit of Bacterial Cytolethal Distending Toxin from <i>Aggregatibacter actinomycetemcomitans</i>
Background Combination cancer therapy is a promising strategy which employs multiple therapeutic agents with different mechanisms of action along with minimal intolerable side eff...
Promoter Hypermethylation Analysis of the Tumor Suppressor Genes RASSF1A and RASSF2A in Iranian Endometrial Carcinoma Patients
Introduction The endometrial cancer (EC) is the seventh most common malignancies worldwide among females with good prognosis in early stages of the disease. The CpG Island in the...