The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis
Journal Title: THE ULUTAS MEDICAL JOURNAL - Year 2019, Vol 5, Issue 1
Abstract
Introduction: Herpes simplex virus is a common keratitis agent. There are two different types of virus, type 1 and 2. Type 1 shows three main clinical pictures in the cornea: epithelial herpetic keratitis, stromal keratitis, disciform keratitis. The aim of this study is to reduce the duration of herpetic keratitis treatment and eliminate the risk of complications. Material and Methods: Between January 2017 and January 2018, 29 patients with herpetic keratitis were included in the study. In the first group, the herpetic membrane was removed by a single shot on the herpetic lesion with the yag laser. Then, topically oxytetracycline hydrochloride+polymyxin B sulfate was applied. The second group was treated with topical antiviral therapy (Ganciclovir). After treatment, daily follow-up of patients, vision, tonus, fundus diameters and recovery times were noted and the data were compared statistically. Results: In group I and group II, the age of the patients did not differ significantly (p> 0.05). In group I and group II, the gender distribution of the patients did not differ significantly (p>0.05). In Group I and Group II, the degree of vision did not differ significantly (p>0.05). In group I and group II, the examination findings were not significant (p>0.05). In group I and group II, recovery time was significantly different (p<0.05). Conclusion: Oxytetracycline HCl + polymyxin B sulfate may be superior to ganciclovir for treating herpetic epithelial keratitis.
Authors and Affiliations
Oguz Guvenmez, Asim Kayiklik
Keywords
Related Articles
- EP ID EP609212
- DOI 10.5455/umj.20191024045517
- Views 112
- Downloads 0
Treatment Response to Phototherapy in Patients with Mycosis Fungoides and Parapsoriasis
Background: Early stage mycosis fungoides (MF) and parapsoriasis are treated by phototherapy techniques. In this study, we aimed to assess treatment responses to narrow-band ultraviolet B (NB-UVB) and psoralen plus ultra...
Comparison of Efficacy and Tolerability of Modified Release Methylphenidate, Osmotic-Release Methylphenidate and Atomoxetine in Children with Attention Deficit Hyperactivity Disorder
Background: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition that affects the daily functioning of children, adolescents, and adults. In this study, we aim to determine the efficacy and t...
Correlation of Maternal and Cord Blood Leptin Concentrations with Neonatal Birth Weight in Term, Preterm and Growth-Restricted Fetuses
Background: To determine the association of cord blood and maternal leptin levels with neonatal birth weight in preterm deliveries, intrauterine growth-retarded neonates, and term neonates. Materials and Methods: Sixty p...
A Fatal Case of Aspergillus Empyema
We described a fatal case of Aspergillus empyema in a patient with COPD. Although Aspergillus empyema is extremely rare,1-3 this clinical entity is associated with high morbidity and mortality. As the previous investigat...
The Effect of Delivery Mode on the Female Sexual Function Index
Background: Sexual function is one of the parameters affecting female life and life quality. We aimed to examine the effect of delivery mode on female sexual functions. Materials and methods: Female sexual function in...