The effectiveness of immunoglobulin-G in patients with DRTB/HIV in a state of expressive immunosuppression according to hematological studies
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 1
Abstract
Objective — to study hematological disorders in patients with coinfection of DR TB/HIV in a state of significant immunosuppression, and to evaluate the effectiveness of immunoglobulin therapy by IgG. Materials and methods. 52 patients with DRTB/HIV aged from 20 to 55 years with CD4 lymphocyte counts up to 50 cells/µl were examined. Patients were divided into two groups: 1st (control) — 26 patients received standard treatment with secondline antituberculosis drugs with antiretroviral therapy; 2nd (main) — 26 patients received additional intravenous IgG in complex therapy. Results and discussion. Before the beginning of antituberculous therapy, leukocytosis was observed 3.2 times more in patients of both groups than leukopenia (50 and 15.4 %, respectively); lymphopenia was 7.3 times higher than leukocytosis in the first group and 9.3 times in the second group. Monocytopenia was noted in (76.9 ± 1.69) %, monocytosis in (15.4 ± 1.44) % of patients of the first group and monocytopenia (73.1 ± 1.77) and monocytosis (15.4 ± 1, 44) % in the second group. That is, almost five times more often monocytopenia was registered. Eosinophilia was determined in both groups with a frequency (15.4 ± 1.44) %. The level of neutrophils increased in (69.2 ± 1.85) and (73.1 ± 1.77) % of patients in the first and second groups, respectively. Anemia of mild and moderate degree was recorded in the same amount — in (38.5 ± 1.95) % of patients of the first and second groups, and severe anemia in (11.5 ± 1.28) % in the first group and (15.4 ± 1.44) % — in the second. Thrombocytopenia was diagnosed in (34.6 ± 1.91) and (38.5 ± 1.95) % of patients in the 1st and 2nd groups, respectively. Conclusions. In patients of group 1, after 2 weeks of treatment, leukocytosis, neutrophilia, and lymphopenia were observed in patients of the 2 group, because of adherence to the course of intravenous IgG treatment, a decrease in the level of leukocytes and neutrophils was observed. Also, there was a decrease in the manifestations of anemia, due to a decrease in the toxic load on the organs of hematopoiesis.
Authors and Affiliations
N. А. Matsegora, A. V. Kaprosh
Keywords
Related Articles
- EP ID EP280637
- DOI -
- Views 130
- Downloads 0
Experience of selection, indication and identication of non-tuberculous mycobacteria, got during I National research on study of distribution of drugresistant of tuberculosis in Ukraine
Objective — a study of presence of non-tuberculosis mycobacteriumin a circulatory mycobacterial population among patients by a white plague in Ukraine, finding out of etiologic role of non-tuberculosis mycobacterium, the...
Lung pathology and causes of death among hospitalized adult patients with HIV infection: pathological analysis
Objective — to analyze medical records, clinical and laboratory research data and autopsies of deceased HIVinfected adults in the hospital, to assess the level of coincidences and discrepancies of clinical and pathologi...
New approaches in latent TB infection detection and management
The review of WHO approaches related to latent TB infection (LTI) is presented. Prospective of different methods of LTI testing in Ukraine given significant TB burden and insufficient domestic resources is discussed. Giv...
Predictors of development of HIV-associated neurological diseases
Objective — to study the impact of demographic, epidemiological and genetic factors on the course of HIV infection and manifestation of neurological diseases. Materials and methods. The study involved 70 patients with t...
Errors in the radiation diagnostics in patients with syndrome of pleural effusion
Objective — to bring to the general medical community the main causes of diagnostic errors in the choice of the method of initial radiation examination for the diagnosis of effusion in the pleural cavity. Materials and...