The effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder: A randomized clinical trial
Journal Title: Electronic Physician - Year 2017, Vol 9, Issue 11
Abstract
BACKGROUND: Different studies have been conducted to find the best adjuvant therapies for depression management. There are controversies over the effects of aspirin as an adjuvant therapy for depression. OBJECTIVE: To determine the effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder. METHODS: This randomized clinical trial was conducted at Kargarnejad Psychiatric Hospital in Kashan, Isfahan, Iran, from September 1, 2016 to November 1, 2016. The study participants included 100 patients with major depressive disorder who were assigned to aspirin and placebo groups by the use of computer-generated random numbers. Patients in these groups respectively received sertraline-aspirin and sertraline-placebo for eight consecutive weeks. Patients were prescribed 80 milligrams of aspirin twice a day. Also, sertraline was administered at a dose of 50-200 milligrams daily. Beck Depression Inventory was employed for depression severity assessment at four time points, namely before, two, four, and eight weeks after the beginning of the intervention. Medication side effects were also assessed eight weeks after the beginning of the intervention. Data were analyzed by SPSS version 12.0, using Chi-square and the Independent-samples t-test (α=0.05). RESULTS: Both groups were matched in terms of age (p=0.46), gender (p=0.539), and depression severity (p=0.509, with mean score 33.5±4.1 vs. 32.8±5.9) at baseline. However, depression scores were reduced significantly four and eight weeks after initiation of therapy just in the sertraline-aspirin group (p<0.05). CONCLUSION: As an adjuvant therapy, aspirin can reduce depression severity among patients with major depressive disorder. Yet, further studies are needed to prove the effectiveness of aspirin and other anti-inflammatory agents in reducing depression severity. TRIAL REGISTRATION: The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the IRCT ID: IRCT2016082829556N1. FUNDING: The authors received financial support from Research Deputy of Kashan University of Medical Sciences, Kashan, Isfahan, Iran
Authors and Affiliations
Zahra Sepehrmanesh, Hosein Fahimi, Goudarz Akasheh, Mohamadreza Davoudi, Hamidreza Gilasi, Amir Ghaderi
Keywords
Related Articles
- EP ID EP333035
- DOI 10.19082/5770
- Views 112
- Downloads 0
Determinants of pharmaceutical expenditures of urban households: A time series study in Kermanshah province (Iran).
In recent decades, the development of medical and pharmaceutical science has led to a heavy financial burden on the government, insurance companies, and the general population. Due to the increasing the cost of pharmaceu...
Maternal-fetal Rhesus (Rh) factor incompatibility in Arar, northern Saudi Arabia
BACKGROUND AND AIM: Rh isoimmunization still contributes to the neonatal morbidity and mortality due to non-immunization, under-immunization, and in rare cases, false Rh typing. The main objective of this study was to de...
The association between parental mental health and behavioral disorders in pre-school children
BACKGROUND AND AIM: Behavioral disorders among children reflect psychological problems of parents, as mental illness of either parent would increase the likelihood of mental disorder in the child. In view of the negative...
Giardia Intestinalis in the general population and dogs of a rural area, Central part of Hamadan, in western Iran.
This is a Short Report Aticle. Then, does not need an abstract. See the full text.
A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua
Artemisia annua belongs to the asteraceae family, indigenous to the mild climate of Asia. The aim of this study was to overview its anti-malarial properties, immunosuppressive properties, anti-inflammatory properties and...