The Effects of Endurance Training and Gallic Acid on BDNF and TNF-a in Male Rats with Alzheimer
Journal Title: International Journal of Applied Exercise Physiology - Year 2016, Vol 5, Issue 4
Abstract
Background: In the present study, the effects of endurance training and chronic administration of Gallic acid (GA) on hippocampal level of brain-derived neurotrophic factor (BDNF) and tumor necrosis factor alpha (TNF-α) in trimethyltin (TMT)-induced hippocampal degeneration as a model of Alzheimer’s disease were investigated. Methods: 70 male Sprague-Dawley rats were selected and randomly assigned to 7 groups: 1.control, 2.TMT, 3.TMT+GA50, 4.TMT+GA100, 5.TMT+Ex, 6.TMT+Ex+GA50, 7.TMT+Ex+GA100. For induction of Alzheimer's disease, the rats in groups 2-7 were injected with single dose of TMT (8 mg/kg), intra-peritonealy (i.p.). Rats in the groups 5, 6 and 7 carried out an 8-week exercise program on a motorized treadmill (15-20 m/min, 0% inclination for 15- 30 min/day, 5 days/week). In addition, the groups 3 and 6 were treated by 50 mg /kg and groups 4 and 7 are administered 100 mg/ kg of Gallic acid for 2 weeks. Then, the hippocampal level of BDNF and TNF-α was performed for all groups by Elisa. Results: The findings of present study showed that the hippocampal level of BDNF in all test groups are significantly higher than TMT group (p≤0.05) and the hippocampal level of TNF-a in all test groups is significantly less than the TMT group (p≤0.05). Conclusion: Endurance exercises training, chronic administration of GA and co-treatment with training and GA consumption specially, having sufficient neurotrophic and immune modulator effects in male rats with Alzheimer.
Authors and Affiliations
Mohammad Amin Edalatmanesh, Yoones Baziyar, Seyed Ali Hosseini, Abdossaleh Zar
Keywords
Related Articles
- EP ID EP567946
- DOI -
- Views 81
- Downloads 0
Civil Liability Resulting from Sport Referees Misjudgment
There is no doubt that sport is helping people to have health and happiness. However, this has undergone several changes over time since but there was professional the sports mix with championship and all there phenomena...
Molecular Signals and Skeletal Muscle Adaptation to Exercise
The phenotypic plasticity of skeletal muscle affords a considerable degree of adaptability not seen in other bodily tissues. The mechanical properties of skeletal muscle are highly dependent on loading conditions. The ex...
Effects of twelve weeks of aerobic training, resistance training or combination of both trainings on the levels of blood sugar, HbA1c and cardiovascular risk factors in women with type 2 diabetes
Introduction and purpose: Diabetes mellitus is a metabolic disease that is brought about by either insufficient production of insulin or the inability of the body to respond to the insulin formed within the system. The a...
Effect of 8-Week Aquatic, Land- based and Combined (Aquatic-Land) Training Programs On Walking Capacity in Women with Multiple Sclerosis (MS): A Burdenko Approach
Multiple sclerosis (MS) is a chronic disease affecting all aspects of life in patients with this disease and causes a wide range of functional problems, including reduced walking capacity. The aim of this study was to co...
Association between Physical Activity and Serum Bilirubin Levels and Its Potential Modulating Effect in Trained and Untrained Adult Males
Why studies over the last two decades had shown low levels of serum bilirubin to be associated with high risk for varieties of systemic diseases in human, we propose that one potential modifiable behavior to increase bil...