The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats
Journal Title: Cumhuriyet Science journal - Year 2017, Vol 38, Issue 3
Abstract
The purpose of our studies is to assist in fully understanding the role of oxytocin in the live metabolism by examining the effects of oxytocin, oxytocin receptor antagonist atosiban, and oxytocin-atosiban chemicals injected to the rats on activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in the lung tissue of the rats. For this purpose, 4 different groups each of which contains 6 rats formed. (Control group, oxytocin administered group, atosiban administered group, and both oxytocin and atosiban administered group). The rats were necropsied after an hour from the injection of chemicals into the rats intraperitoneally. The lung tissues of the rats were extracted. Carbonic anhydrase and acetylcholinesterase enzymes activities were measured for the tissues. All the experimental results were provided as mean ± SD (mean standard deviation). Because of the data was compatible with the normal range, it was tested via variance analysis (ANOVA) and then, significance was determined by the Tukey test. Statistical significance was identified to be p <0.05. Accordingly, it was observed that there was neither a decrease of enzyme activities in oxytocin and atosiban administered groups, nor a significant change of enzyme activities in both oxytocin and atosiban administered group. Also, we observed that oxytocin reduced carbonic anhydrase enzyme activity as a systemic effect. We think that this result may contribute to remedy of lung related diseases progressing with oxygen and carbon dioxide transport disorders.
Authors and Affiliations
Ümit M. KOÇYİĞİT
Keywords
Related Articles
- EP ID EP488317
- DOI 10.17776/csj.340483
- Views 54
- Downloads 0
Iron Interstitial Defects Stability: Under the Uniaxial Stress Effect
Understanding of defect kinetics under stress fields is important for multiscale modeling of nuclear materials degradation. By means of molecular dynamics (MD) simulation, the formation and migration energies were evalua...
Consistent Empirical Physical Formula Construction for Gamma Ray Angular Distribution Coefficients by Layered Feedforward Neural Network
Multipolarities of gamma rays and spins-parities of nuclear states are usually investigated by the angular distribution of gamma rays emitted from aligned states formed by nuclear reactions. For different multipolarities...
New Composite, Poly(Hydroxyethylmethacrylate-Expanded Perlite), for Single step Separation of Egg White Lysozyme
In this study, we investigated adsorption behaviour of lysozyme on poly(hydroxyethylmethacrylate-expanded perlite) [P(Hema-Ep)]. For this purpose, we synthesized P(Hema-Ep) composite by bulk polymerization and it was cha...
The Local Stability Analysis of a Nonlinear Discrete-Time Population Model with Delay and Allee Effect
In this work, we present a delay general nonlinear discrete-time population model with and without Allee effects which occur at low population density. We investigated local stability conditions of equilibrium point of b...
Selfadjointness and Positiveness of the Differential Operators Generated by New Type Sturm-Liouville Problems
It is purpose of this paper to investigate Sturm-Liouville equation on many-interval with the eigenvalue parameter appearing linearly in the boundary conditions and with two supplementary transmission conditions. The cla...