THE EFFECTS OF PHYSICAL EXERCISE ON THE INSULIN-DEPENDENT DIABETES MELLITUS SUBJECTS USING THE MODIFIED MINIMAL MODEL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2017, Vol 9, Issue 2
Abstract
Objective: In this paper, the modiï¬ed minimal model (MM) with a mathematical function for describing the insulin infusion rates was used to study of the effects of physical exercise on the dynamics of glucose and insulin on the insulin dependent diabetes mellitus (IDDM), including type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) subjects.Methods: In an intravenous glucose tolerance test (IVGTT) procedure, a dose of glucose was administered intravenously to overnight-fasted subjects, 20 min after the glucose bolus, insulin was injected over 1-2 min either into the portal vein or into the femoral vein, and subsequently the glucose and insulin concentrations in plasma were frequently sampled (usually 30 times) over a period of 180 min. The dynamic glucose and insulin responses to glucose and insulin injection were analysed using the modified MM without and with physical exercise from IVGTT data.Results: Our simulation results shown physical exercise improved blood glucose control and enhanced insulin sensitivity (SI) index in subjects with T1DM and T2DM. However, the T1DM and T2DM subjects need to be aware of the basic strategies to prevent hypoglycemia and maintain reasonable glucose control. It should be noted that the putative improvement in exercise-induced peripheral SI index in subjects with T1DM and T2DM was not always coincidental with the improvement of the insulin dosage.Conclusion: The feature increased physical exercise, along with knowledge about how to modify daily insulin dosage to prevent hypoglycemia, improved blood glucose control and enhanced SI index.Â
Authors and Affiliations
Agus Kartono, Febri Dwi Irawati, Ardian Arif Setiawan, Heriyanto Syafutra, Tony Sumaryada
Keywords
Related Articles
- EP ID EP575838
- DOI 10.22159/ijpps.2017v9i2.15621
- Views 60
- Downloads 0
THE RED BUTTERFLY WING (CHRISTIA VESPERTILIONIS): A PROMISING CANCER CURE IN MALAYSIA
No Abstract Needed
FORCE DEGRADATION STUDY AND RP-HPLC METHOD DEVELOPMENT FOR ESTIMATION OF FLUVOXAMINE MALEATE IN TABLET
Objective: To evaluate stability of drug by force degradation studies and to develop validated RP-HPLC method for quantitative estimation of fluvoxamine maleate in pharmaceutical dosage form.Methods: The optimized chroma...
IN VITRO EQUIVALENCE STUDY OF GENERIC NAPROXEN SODIUM TABLETS USING THE USP PADDLE APPARATUS AND THE FLOW-THROUGH CELL METHOD
Objective: To perform an in vitro equivalence study of naproxen sodium from six immediate release oral dosage forms under the hydrodynamic environments generated by the flow-through cell method and the USP paddle apparat...
DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME MANNICH BASE DERIVATIVE OF 2-(SUBTITUTED)-5-AMINO-THIADIAZOLES
Objective: The major objective of the present study was to design, synthesize some Mannich base derivative of 2-substituted-5-amino thiadiazoles with primary amines/phthalimide and formaldehyde anticipating effective as...
1,2,4-TRIAZOLES: SYNTHETIC STRATEGIES AND PHARMACOLOGICAL PROFILES
Multicomponent, solid-phase, microwave and grinding methods are the constructive modes in the sustainable synthesis of 1, 2, 4-triazoles and such reactions have attracted enormous interest in recent years. The alternativ...