The Effects of Thermally Oxidized Palm Oil on the Kidney of Adult Wistar Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 4
Abstract
This study was aimed at the histological changes that might occur following the ingestion of thermallyoxidized palm oil. The study was prompted by rising reports of toxicity of thermoxidized palm oil to bodytissues and organs following ingestion, and palm oil happens to be the most widely consumed oil especiallyin Nigeria as it is a core ingredient of many Nigerian diets. Sixteen wistar rats of an average weight of 180gwere used for this study and were divided into four groups of four rats in each group. Group A served as thecontrol, receiving normal feed (grower mash), group B received a diet containing 20% fresh palm oil and80% of normal feed. Group C received a diet containing 15% thermoxidized palm oil and 85% normal feed.Group D received a diet containing 20% thermoxidized palm oil and 80% normal feed. The animals weresacrificed after 28days (1month) of administration. The results showed that consumption of thermallyoxidized palm oil had a negative effect on the histological appearance of the kidney ranging fromvacuolation and degeneration of renal corpuscle, tubular necrosis, patches/diffused denudation of the renaltubular cells with loss of brush border; to accumulation of homogenous substances with eosinophilic debris,suggesting acute renal failure. Excessive ingestion of fresh palm oil was also seen to be unsafe as it inducedvacuolation of renal corpuscles and tubular necrosis. From the result of this study, I recommend thatingestion of thermoxidized palm oil should be avoided and also, there should be a controlled ingestion offresh palm oil in adequate quantity
Authors and Affiliations
Boniface MN
Keywords
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