The evaluation of ovarian reserve and menstrual irregularities in female patients treated with systemic isotretinoin
Journal Title: Turkderm-Turkish Archives of Dermatology and Venereology - Year 2020, Vol 54, Issue 3
Abstract
Background and Design: Isotretinoin is a widely used retinoid for the treatment of many dermatological conditions notably in acne with many known side effects. This study aims to investigate the effects of isotretinoin on anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH) and total antral follicle count (TAFC) as the indicators of ovarian reserve (OR) and also aims to investigate the frequency of menstrual irregularities (MI). Materials and Methods: Ninety-two reproductive women were included in this prospective controlled study. Study group is consisted of 32 healthy control, 29 low-dose (0.4-0.6 mg/kg/day mean: 0.56±0.06) and 31 high-dose isotretinoin received patients (0.7-1.1 mg/kg/day mean: 0.94±0.11). AMH, FSH and TAFC were evaluated before and at 6th month of treatment in the treatment group, while AMH and FSH levels were evaluated in the control group. Results: Mean AMH level of treatment group at the 6th month of treatment was significantly lower than the level prior to treatment and that of the control group (p<0.001, p=0.013). Mean FSH level was increased, and TAFC level was decreased compared to pretreatment period (p=0,912, p=0,824). Seventeen patients (28.3%) had MI during treatment. Conclusion: Although decrease in antral follicle numbers and increase in FSH levels were not significant, significant decreases in AMH levels may indicate the negative effect of isotretinoin on OR.
Authors and Affiliations
Pelin Can, Emek Kocatürk, Veli Mihmanlı, Veysel Sucu, Ece Nur Degirmentepe, Utkan Kızıltaç
Keywords
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- EP ID EP689144
- DOI 10.4274/turkderm.galenos.2020.37974
- Views 155
- Downloads 0
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