The frequency of genotypes for the SNP Ser/Ser in the studied population of Albanian women is higher in the Balkan region
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 8
Abstract
In women undergoing natural cycles, just one oocyte is usually selected for ovulation, yet routine clinical techniques to support the development of multiple follicles using additional gonadotrophins result in numerous ovulations. Several parameters have been postulated as predictors of ovarian response (inhibin B, 17-β-estradiol and antiMüllerian hormone). Nevertheless, the FSH level on the day 3 of menstrual cycle remains, the most widely used biomarker due to its low cost, although, the genetic background of individuals seems to determine the response of patients to rFSH stimulation better than the stimulation design. Consequently, the variants of FSHR were explored and they may be involved in the role of FSH receptor in mediated signal transduction and with ovarian response in infertile women submitted to ovarian stimulation. In this study we examined, for the first time, the prevalence of genotype variants Asn680Ser in population Albanian women from Kosovo Dukagjin region who took part in IVF / ICSI program. The frequencies of the Asn680Ser genotype variants were as follows: Asn/Asn 22.1%, Asn/Ser 47.1%, and Ser/Ser 30.8%, respectively (Table 1). bE2 levels between the three genotype variants showed slight but statistically significant difference (p= 0.0308). No difference was also found between the genotype groups either in terms of AFC, amount of the FSH required for ovulation induction, stimulation length days, number of dominant follicles, oocyte retrieval number or endometrial thickness (Table 2). BMI was significantly higher in the Ser/Ser group as compared to those from the Asn/Ser or the Asn/Asn group (p= 0.0010) (Table 2). In the study population of Albanian women Dukagjin region of Kosovo had a higher incidence of Ser / SER genotype compared to Asn / Asn genotype. Our research results in the Albanian population differ from published data for other ethnic groups in the Balkans.
Authors and Affiliations
Zafer Gashi| Infertyliti center, Peje, Kosovo, Shkelzen Elezaj| Regional Hospital, Peje, Kosovo Corresponding email:shkelzenelezaj@yahoo.com, Afrim Zeqiraj| Infertyliti center, Peje, Kosovo, Driton Grabanica| Mother Teresa”Medical Center Kline, Kosovo.Ko, Isak Shabanaj| Ministry of Health Pristina, Kosovo, Fitore Gashi| Faculty of Medicine Prishtine, Kosovo
Keywords
Related Articles
- EP ID EP11918
- DOI -
- Views 313
- Downloads 12
ANCIENT SCHWANNOMA OF THE CERVICAL VAGUS NERVE: A RARE BENIGN NEUROGENIC TUMOR
Schwannomas are benign, slow-growing encapsulated tumors that originate from Schwann cells of the nerve sheaths. Schwannoma originating from the cervical vagus nerve is an extremely rare neoplasm that usually occurs in...
Management of intra-articular fractures of distal humerus with two column fixation with orthogonal plate construct
Accurate reconstruction of articular surface of distal humerus by closed manipulation is not possible. The recent trend for displaced intra-articular fractures of the distal humerus is open reduction and stable osteosyn...
Effect of vaginal progesterone suppository (200 mg) on preventing preterm labor after the inhibition of uterine contractions: A randomized clinical trial
Preterm labor implies a childbirth before the completion of 37 weeks, and accounts for the majority of infant mortalities. Finding proper medications is essential in the treatment procedure. The present research aimed t...
Use of Machine-Learning Approaches to Predict Clinical Deterioration in Critically Ill Patients: A Systematic Review
Introduction: Early identifcation of patients with unexpected clinical deterioration is a matter of serious concern. Previous studies have shown that early intervention on a patient whose health is deteriorating improve...
Investigating the prevalence of personality disorders and its relationship with personality traits among students
The present study was aimed to investigate the prevalence of personality disorders and its relationship with personality traits among students. This research was among epidemiological-correlational descriptive studies....