THE IMPACT OF METHYLENETETRAHYDROFOLATE REEDUCATES GENE POLYMORPHISMS ON IRAQI PATIENTS WITH DIABETIC NEPHROPATHY
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 9
Abstract
Diabetic nephropathy is a major cause of end-stage renal disease. Micro albuminuria is a term to describe a moderate increase in the level of urine albumin. It occurs when the kidney leaks mall amounts of albumin into the urine. The aim of this study was to investigate the influence of the C677T and A1298C polymorphisms of methylene tetrahydrofolate on the progression of chronic kidney disease in diabetic nephropathy of Iraqi patients to delay the deterioration in renal function. A hospital-based case-control study was performed. A total of 60 patients with diabetic nephropathy age (24-87) and 60 controls age(16-68) selected from nephrology center in Bagdad Teaching Hospital /Medical City from December 2017 until the end of August 2018, shows mean differences of study markers including (FBS, Blood urea, Serum creatinine and MTHFR) according to study group (micro albuminuria and control group). There were significant differences between means of all markers according to study group.in result conclusion Urinary biomarkers were significantly elevated in normoalbuminuric type 2 diabetic patients compared with non-diabetic control subjects and could be used as markers of diabetic nephropathy( DN) at a very early stage even before the development of micro albuminuria.
Authors and Affiliations
Safa A. Ali
Keywords
Related Articles
- EP ID EP669124
- DOI -
- Views 144
- Downloads 0
WRIGHTIA TINCTORIA: A SHORT REVIEW
Different parts of Wrightia tinctoria R. Br. (Apocynaceae) (W. tinctoria), have been extensively used in Indian systems of medicine such as Ayurveda, Siddha and Unani for the treatment of jaundice, malaria, psoriasis and...
AUSHADHA SEVAN KAALA A REVIEW
Aushadha sutra, one of a trisutra and must taken into consideration while doing chikitsa (treatment). Trisutra Ayurved is of prime importance while treating a patient. Hetu (causative factors), linga (signs and symptoms)...
EVALUATION OF THE INTERACTION OF THREE TYPES OF ANTRACICLINES AND NEUROTRASMISORS USING QUANTIC CHEMICAL SIMULATION
In this work we analyze three types of anthracyclines (ACys). The analysis consists of observing how these ACys interact with the neurotransmitters (NT). These drugs are used in the treatment of different types of cancer...
BIOEQUIVALENCE STUDY OF TWO ORAL OXYTETRACYCLINE FORMULATIONS (OXYTETRACYCLINE 50%® AND TETRAMED®) IN BROILER CHICKENS
The present study was designed to assess the comparative bio-equivalence of Oxytetracycline 50%® and Tetramed® in healthy broiler chickens after oral administration of both products in a dose of 20 mg oxytetracycline/kg....
EDUCATION ON SEXUAL DYSFUNCTION IN PARAPLEGIC MALES
Introduction: Spinal cord injury is a traumatic, life changing event for the injured person. It alters the motor, sensory and autonomic functions, which affects many areas of an individual’s life including his sexual act...