The influence of metabolites from wild type and mutant strains of Schizophyllum commune on Escherichia coli induced changes in Albino rats
Journal Title: Scholars Academic Journal of Biosciences - Year 2013, Vol 1, Issue 4
Abstract
The increasing emergence of several multi-resistant pathogenic microorganisms to synthetic drugs has drawn much attention of researchers to finding new, attractive and natural products such as mushroom species as neutraceuticals because they contain a tremendous variety of secondary metabolites. Hence this work is reported on the influence of metabolites fromSchizophyllum commune wild type and mutants on Escherichia coli induced histopathological changes in Albino rats. S. commune mutant strains were generated by exposing the wild type fungus to ultraviolet rays at various time intervals of 30minutes, 60minutes and 90minutes coded as SCM1, SCM2 and SCM3 respectively. Metabolites from submerged fermentation of the S.commune strains were tested on Albino rats administered with pathogenic E.coli. Histopathological studies carried out on the testes, kidney and liver of the rats showed that SCM2 metabolite performed best in combating the virulence effects of pathogenic E.coli in the testes, kidney and liver tissues of the albino rats as compared to performance of SCM3, SCM1 and SCW respectively, hence SCM2 is recommended for use instead of the wild type in drug production. Keywords: Metabolites, Schizophyllum commune, Albino rats, Submerged fermentation.
Authors and Affiliations
Aina . , Alatise . , Akeredolu . , A. A. , Oloke . , J. K. , F. A, Omomowo . , D. A. , I. O.
Keywords
Related Articles
- EP ID EP377790
- DOI -
- Views 67
- Downloads 0
Changes of anthocyanin, vitamin C content and antioxidant activities of purple cabbage pickle during fermentation process
Pickle was made using the purple cabbage as raw material to ferment, and the changes of anthocyanin, vitamin C content and antioxidant activities of purple cabbage pickle during fermentation process were investigated. Th...
Normal Menstrual pattern profile
Menstrual cycle is a regular natural change in the female reproductive system which prepares the uterus for pregnancy. Commencement of menstrual cycle is considered as sign of puberty. The study was undertaken to know th...
Correlates of the Prevalence of Soil Transmitted Helminth (STH) Infection among Selected Students of Cataggaman National High School, Tuguegarao City
Abstract: Soil-transmitted Helminth (STH) infections are one of the causes of morbidity among high school students. This study was aimed to assess the prevalence as well as the correlates of the prevalence of STH infecti...
Oral and Dental Health Knowledge, Attitude and Practice among Pregnant Women
The objective of the study was to assess women’s knowledge and attitude towards oral and dental health during pregnancy and to examine their self-care practices in relation to oral and dental health. This was a hospital...
Anti-Diarrhoeal Activity of Ethanolic Leaf Extract of LuffaAcutangulaagainst Castor Oil Induced Diarrhoea in Rats
Diarrhea is a symptom marked by rapid and frequent passage of semisolid or liquid fecal material through the gastrointestinal tract and involves both an increase in the motility of the gastrointestinal tract along with i...