The Investigation of Ghrelin and Aerobic Exercise Effects on Anxiety Related Behavior in Adult Male Rats
Journal Title: The 2nd Annual Meeting of International Center for Neuroscience Research - Year 2021, Vol 2, Issue 1
Abstract
Aim: Anxiety is one of the most important health problems in societies which affecting millions of individuals all over the world. Ghrelin plays pivotal roles in central nervous system functions and their disorders such as anxiety, learning and memory status. Also scientific evidences show that physical activity is associated with reduced feelings of anxiety by increasing levels of some neurotrophic factors. Therefore, in this study we aimed to evaluate the coincident effects of ghrelin and aerobic exercise on anxiety-like behavior in rats. Methods: Forty male Wistar rats (250 ± 20 g) were divided into 5 groups (n=8) and received intra-hippocampal injection of ghrelin (3nM), performed aerobic exercise training for 8 weeks or both treatments. Control groups received same volume of saline and diazepam as negative and positive control groups, respectively. After the ending of treatments, anxiety-like behavior was recorded by the elevated plus maze test. Results: Our findings showed that ghrelin enhances anxiety-related behaviors in male rats in the EPM task. They spent significantly less time in open arms and fewer open arms entries than control group (P<0.05). The results showed that exercising rats spent more time in the open arm zone suggesting that physical activity reduces anxiety-like behavior (p<0.01). Moreover, comparing between the exercise + ghrelin group function with both of exercise and ghrelin groups indicate that these two factors have not a synergistic effect on anxiety-like behaviors. Conclusion: The results of this study demonstrated that physical activity alleviates anxiety-related behaviors and intra-hippocampal injection of ghrelin increases anxiety status in rats.
Authors and Affiliations
Mohaya Farzin, Parvin Babaei, Mohammad Rostampour*
Keywords
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