The issues of concern in the modern pharmacotherapy the gastroesophageal reflux disease: the role and place of prokinetics
Journal Title: Сучасна гастроентерологія - Year 2018, Vol 0, Issue 1
Abstract
The article presents review of modern concepts of the pathophysiological mechanisms of gastroesophageal reflux disease (GERD) development. The issues of the increasing resistance to proton pump inhibitors (PPI) in the course of GERD treatment have been considered. The clinical and pathophysiological substantiation has been provided for the prokinetics use in the GERD treatment under conditions of ineffective PPI. The advantages of domperidone are described from the standpoint of both anti-reflux effect and safety profile.
Authors and Affiliations
I. G. Paliy, S. V. Zaika, S. P. Kolisnyk, I. V. Tkachuk
Keywords
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