The middle mass molecules and oligopeptides content in rat blood and tissues under the acid esophagus burn conditions
Journal Title: Naukovyi visnyk Chernivetskoho universytetu. Biolohiia (Biolohichni systemy) - Year 2015, Vol 7, Issue 2
Abstract
The burn was accompanied by prolonged protein metabolism disorders, which led to the pathological changes in the various organs and systems functioning. The main diagnostic criterion of the acid burn severity is the total protein and albumin levels. These parameters are the major biochemical blood serum indicators that can characterize the functional state of the organism and to assess the degree of metabolic disorders under the studied pathology. The level of these indicators was the most declined at the 1st and 7th days after acid treatment comparing with the control values. The endogenous intoxication after the acid burns the esophagus 2 degrees in immature rats modelling is shown. The markers of endogenous intoxication (oligopeptides and middle mass molecules) in the blood serum of immature rats were increased on the 1st day of experiment. acid burns the esophagus. The above mentioned parameters of endogenous intoxication were measured in liver, spleen, mucosa of the esophagus rat cell homogenates and they had the highest level for 15, 21 days under the conditions of the second-degree acid esophagus burn. The level of the middle mass molecules and oligopeptides varied depending on the metabolic state of the organism and was prognostic criterion of metabolic disorders. This substances accumulation is not only a marker of endointoxication, they could further reinforce the pathological processes acquiring the secondary toxic role and affecting the livelihoods of all systems and organs. In this regard, the searching of the agents having anti-toxic properties is exceedingly important for the burn patients’ treatment.
Authors and Affiliations
Т. Коваль, Я. Раєцька, О. Савчук, Людмила Остапченко
Keywords
Related Articles
- EP ID EP235722
- DOI -
- Views 379
- Downloads 0
The intensity of free radical processes in the liver mitochondrial fraction under the conditions of toxic injury and correction by the 3,4-dihydropyrimidine-2-one ammonium derivative
The research deals with the determination of the superoxide-anion radical, TBA-active products and protein carbonyl derivatives content in the protein-deficient rat liver mitochondrial fraction under the conditions of ac...
ХАРАКТЕРИСТИКА ФУНКЦІОНУВАННЯ ДЕЯКИХ КОМПОНЕНТІВ АНТИОКСИДАНТНОЇ СИСТЕМИ РОСЛИН В ТКАНИНАХ LIGULARIA GLAUCA (L.) HOFFM. І L. SIBIRICA (CASS.) ЗА РІЗНИХ УМОВ ВИРОЩУВАННЯ
На основі аналізу кількісного вмісту суми поліфенолів і флавоноїдів та поліфенолоксидазної активності експлантів Ligularia glauca (L.) J. Hoffm. і L. sibirica (Cass.) проаналізовані особливості функціонування системи ант...
Biomorphological features of the Salicornia perennans Willd. (Сhenopodiaceae) in the Steppe of Ukraine
The research results of the biomorphological features of Salicornia perennans Willd (Chenopodiaceae) in conditions of saline areas of the Ukraine Steppe are generalized. It has been shown that the plants are herbaceous a...
КАРТУВАННЯ ВИДІВ АДВЕНТИВНИХ РОСЛИН РОМЕНСЬКО-ПОЛТАВСЬКОГО ГЕОБОТАНІЧНОГО ОКРУГУ
Спираючись на досвід у розробці сіткових карт як локальних територій, так і окремих регіонів, для території Роменсько-Полтавського геоботанічного округу в системі UTM координат підготовлена сіткова карта з розміром комір...
Rhythm of phenology and distribution phenological forms of pedunculate oak (Quercus robur l.) in Donetsk region
The investigation of stands of Quercus robur L. an early-flowering forms and a late-flowering forms in the Donetsk region was performed. The analysis of the phenology rhythm of the two forms pedunculate oaks of the inves...