The obesity paradox in the distribution of dyslipidemia in obese versus non – obese patients of CAD in Gujarati population
Journal Title: Healthline - Year 2014, Vol 5, Issue 1
Abstract
Background: Cardiovascular diseases (CVD) are the major cause of morbidity and mortality in developing countries. Risk factors for CVD like hypertension, diabetes, dyslipidemia and smoking contribute significantly to atherosclerosis and consequently to CVD. The aim of this study was to observe distribution of these risk factors in Gujarati coronary artery disease (CAD) patients over the entire spectrum of BMI and to look for existence of obesity paradox. Methods: This randomized and cross-sectional study was done in September, 2010 on 818 subjects. Subjects of established CAD were evaluated by pretested proforma, physical examinations and, tests of lipid profiles, blood sugar levels. Results: The proportion of hypertension, was significantly higher in >30 BMI group than BMI <25 and 25-30 group (p=<0.0001). Diabetes and dyslipidemia were non-significantly higher in BMI 25-30 than BMI <25 and >30 showing possible effect of obesity paradox. In females, effect of obesity paradox was found in high cholesterol content which was statistically significant (p=0.0465) and low HDL was highest in BMI with <25 than those with BMI with 25-30 and >30 (p=0.1341). The same effect was observed with LDL also but in a non-significant (p=0.6556) fashion. The results found in male population were similar to the females in case of high cholesterol and LDL. Though statistically insignificant the age related dyslipidemia distribution also showed existence of obesity paradox. Conclusion: In females, high cholesterol was more in BMI <25 than BMI 25-30 and >30 group. Same effect was found in males also but did not reach statistically significant level.
Authors and Affiliations
Kamal Sharma, Sanjay Vaghani, Gaurav Gandhi, Nikhil Jadav, Sandarbh Patel, Meena Parmar, Komal Shah
Keywords
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