THE OLFACTORY SYSTEM REGULATES ACUTE MOUNTAIN SICKNESS
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2009, Vol 5, Issue 1
Abstract
OBJECTIVE: Hyperventilation is the first response to hypoxia in high altitude (HA). Our study on rats was designed to establish an integrated hypothesis to include hyperventilation, increased activity of hypothalamic- pituitaryadrenocortical axis (HPA) in response to initial exposure to hypoxia and failure of adaptation to stress in olfactory bulbectomised rats. METHODS: Albino rats whose olfactory lobes were removed were subjected to hypoxia and hypothermic conditions. Blood and urine samples were collected at various stages to measure biochemical parameters. Rats whose olfactory systems were intact were used as controls. RESULTS: The results suggested that the olfactory system regulated pituitary function and that in rats whose olfactory lobes were removed failed to adapt to the stress created by hypoxia and hypothermia. CONCLUSIONS: Acute Mountain Sickness (AMS) is a type of stress. Normal rats when subjected to stress such as AMS are able to adapt. This adaptation is lost when the olfactory bulbs are removed. It is postulated that serotonin receptors in the hypothalamus, through the splanchnic pathway regulate stress. This mechanism is independent of ACTH – Cortisol feed back system. Perhaps irregular and rapid respiratory rhythm simulates physiological Olfactory Bulbectomy during rapid climbing and AMS manifests as a failure of stress adaptation.
Authors and Affiliations
Savitha Nagabhushan, Thuppil Venkatesh, Vidyasagar Casikar
Keywords
Related Articles
- EP ID EP113133
- DOI -
- Views 113
- Downloads 0
Tissue specific responses alter the biomass accumulation in wheat under gradual and sudden salt stress
Salinity is one the major limiting environmental factors which has negative side effects on crop production. The purpose of this study was to investigate the differences between the gradual and sudden salt stress effects...
INDUCTION OF ANAEROBIC PROCESSES IN BAIKAL ENDEMICS EULIMNOGAMMARUS VITTATUS (DYB.) AND E. VERRUCOSUS (DYB.) (AMPHIPODA, CRUSTACEA)
The data confirming the ability of Baikalian endemic species Eulimnogammarus vittatus (Dyb.) and E. verrucosus (Dyb.) to activate anaerobic glycolysis under hypoxia are presented. The differences in the degree and the ra...
Assessment of Platelet in Case of Stress-induced Apnea
Sleep apnea is a independent pathology and a powerful stress for the organism. Apnea is a cause of stress and strengthens the body under stress. We studied 30 men aged 34 to 57 years: 22 patients with obstructive sleep a...
Chemo-protective effect of aqueous extract of the resurrection plant Selaginella involvens (Sw.) Spring on UV-tolerance during spore germination of Pteris argyraea T. Moore
The present study was aimed to know the effect of aqueous extracts of the resurrection plant, [i]Selaginella involvens[/i] (Sw.) Spring on spore germination in [i]Pteris argyraea[/i] T. Moore and also to know the amelior...
Effect of Ionic and Chelate Assisted Hexavalent Chromium on Mung Bean Seedlings (Vigna radiata L. wilczek. var k-851) During Seedling Growth
The effect of Cr[sup]+6[/sup] with and without chelating agents were assessed in mung bean seedlings grown hydroponically. It was noted that the growth parameters showed a declining trend with increasing Cr[sup]+6[/sup]...