The prognostic value of baseline circulating tumor cells in patients with metastatic breast cancer: a meta-analysis
Journal Title: TMR Clinical Research - Year 2020, Vol 3, Issue 4
Abstract
Objective: The prognostic value of circulating tumor cells (CTCs) in metastatic breast cancer (MBC) patients was contentious. A meta-analysis was conducted to evaluate whether MBC patients’ clinical outcomes could be predicted by CTCs detection. Methods: Relevant published studies were searched through electronic databases from January 1990 to February 2018, among which, those investigated the correlation between CTCs and clinical outcomes of progression-free survival and overall survival in MBC patients were involved. The hazard ratios (HR) and confidence intervals (CI) in the studies were extracted from the study using random or fixed effects model, and the meta-analysis was conducted. The prognostic value of tumor cells in patients with different subtypes was estimated by subgroup analysis. Results: Twenty-one eligible studies enrolling 3,837 patients were appropriate for pooled analysis. Progression-free survival (HR, 1.66; 95% CI, 1.47–1.87; P = 0.000) and overall survival (HR, 2.51; 95% CI, 2.13–2.96; P = 0.000) were worse in patients with CTCs-positive. Subtypes of hormone receptor (HorR) positive, human epidermal growth factor receptor-2 (HER2) negative and triple negative with presence of CTCs showed a statistically significant worse PFS and OS. However, CTCs detection presented no prognostic value in patients with HorR-negative or HER2-positive subtypes. Conclusion: The enumeration of CTCs at baseline in patients with MBC subtypes of HorR-positive, HER2-negative and triple negative is connected with disease progression and poor survival, but inappropriate for HorR-negative and HER2-positive subtypes.
Authors and Affiliations
Ling-Mi Hou1# , Fang-Fang Li2#, Lu-Lan Pu3# , Jin-Shui Li1 , Jia-You Liu3 , Yu Chen3 , Yu-Qing Zhou3 , Hong-Wei Yang4 , Shi-Shan Deng3* , Mao-Shan Chen4*
Keywords
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- EP ID EP692786
- DOI 10.12032/TMRCR20201118018
- Views 121
- Downloads 0
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