The Relationship Between TSH Levels and Body Mass Index in Overweight Euthyroid Subjects: Role of Autoimmunity
Journal Title: Journal of Endocrinology and Diabetes - Year 2018, Vol 5, Issue 2
Abstract
Summary: Also if a positive correlation between TSH and BMI has been observed in the majority of the studies, data on this topic remain controversial, especially when TSH values are in normal range. However, it is reasonable to argue that the high-normal levels of TSH found in obesity can be partly attributed to a silent autoimmune thyroiditis. The aim of the present study was to evaluate the interconnection between TSH and autoimmunity in obese patients with TSH values within the normal range. Methods: We enrolled 891 overweight and obese patients (209 Males), with TSH values in normal range (mean age ± SD: 45.1 ± 15 years. Anti thyroid auto antibodies(ATAs: thyroid-peroxides auto antibodies (TPOAb) and/or thyroglobulin auto antibodies(TgAb) and TSH were measured in all patients. The entire sample was then subdivided according to the tertiles of TSH within the range between 0.4 and 4.1 μUI/L. Results: No significant correlation between TSH and BMI was found within these groups. According to the presence (ATA+) or absence (ATA-) of ATAs, we found 225 (25,4%) ATA+ (32 males) and 665 ATA- (177 males) patients. A statistically significant correlation between TSH and BMI was found only in females with ATA positivity (Pearson: r = 0.1426, p= 0.04; Spearman: r = 0.1616, p = 0.02). Conclusion: In the initial assessment of obesity, the determination of TSH could be associate to ATAs, for identifying, among the patients with increased TSH, those affected by autoimmune thyroiditis. We suggest that in these patients, the beginning of LT4 therapy could be taken into account.
Authors and Affiliations
Loviselli A, Sainas GM, Magnani S, Secci G, Pisanu S, Deledda A, Boi A, Lai D, Velluzzi F
Keywords
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- EP ID EP334109
- DOI 10.15226/2374-6890/5/2/01100
- Views 97
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