The Relationship Between Vitamin D Levels and Receptor Activator of Nuclear Factor Ligand in Hashimoto’s Thyroiditis
Journal Title: HASEKİ TIP BÜLTENİ - Year 2017, Vol 55, Issue 4
Abstract
Aim: In order to analyze the relationship of Hashimoto’s thyroiditis with vitamin D and osteoclastogenic markers, we investigated vitamin D, osteoprotegerin (OPG) and receptor activator of nuclear factor ligand (RANKL) levels in patients over 60 years with and without Hashimoto’s thyroiditis. Methods: Eighty three female patients (49 with and 34 without Hashimoto’s thyroiditis), who attended the endocrinology and geriatrics departments between May 2013 and October 2013 were included in the study. Results: There was no statistically significant difference in the levels of vitamin D, OPG and RANKL between the groups. Vitamin D was significantly correlated with OPG and RANKL in patients with Hashimoto’s thyroiditis. In addition, a significant relationship was found between OPG and RANKL levels. Of the patients with Hashimoto’s thyroiditis, 33 were autoantibody-positive and 16 were negative. Vitamin D, OPG and RANKL levels were significantly lower in antibody-positive patients than in negative subjects. Conclucion: There were no differences in vitamin D, OPG and RANKL levels between patients with and without Hashimoto’s thyroidits. Autoantibody-positive Hashimoto’s thyroiditis group had statistically significantly lower vitamin D, OPG and RANKL levels. This reverse correlation suggests that autoantibodies may have an effect on osteoclastogenesis.
Authors and Affiliations
Hakan Yavuzer, Selver Işık, Mahir Cengiz, İbrahim Murat Bolayırlı, Alper Döventaş, Deniz Suna Erdinçler
Keywords
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- EP ID EP251846
- DOI 10.4274/haseki.2193
- Views 93
- Downloads 0
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