The role of E-selectin in inflammatory and atherogenic processes - the impact of hormonal therapy of the menopausal period
Journal Title: Przegląd Menopauzalny - Year 2006, Vol 25, Issue 3
Abstract
E-selectin plays a very important role in phlogistic and atherosclerotic processes of the human organism. Expression of this membrane protein is found on inflammatory endothelial cells as a result of the action of pro-inflammatory cytokines. This protein is also present on atheromatous endothelium with coexisting leucocytic infiltrations. Hormone therapy of the menopausal period favourably reduces E-selectin levels, however this effect is dependent on hormonal doses, type of estrogen and progestogen used as well as on menopausal age, accompanying illnesses and addictions of women qualified for this type of treatment.
Authors and Affiliations
Grzegorz Stachowiak, Tomasz Stetkiewicz, Ireneusz Połać, Anna Sobczuk, Sławomir Jędrzejczyk
Keywords
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