The role of glutamine and α-ketoglutarate in gut metabolism and the potential application in medicine and nutrition
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
An amino acid, Glutamine (Gln), is abundant in both the human body and diet. Gln and its derivatives are important factors affecting intestinal function, growth and development as a main source for energy and structure component. The importance to metabolism is evident during stress. During the past 2 decades, an increased understanding has been gained into its role in metabolism. Gln is currently classified as a conditionally essential amino acid; however, it is unstable in water solution and produces toxic byproducts on decomposition, which has led to the commercialization of its precursor - AKG. Apart from its nutritive role, Gln and AKG possess certain pharmacologic and/or immunologic effects. The article presents the role of Gln and AKG in gut metabolism and, on the basis of clinical trials and animal experiments, discusses their potential usefulness in medicine and nutrition.
Authors and Affiliations
Rafał Filip, Stefan G. Pierzynowski
Keywords
Related Articles
- EP ID EP58558
- DOI -
- Views 108
- Downloads 0
Effect of fribrinigen degradation products on various stages of the fibrinolytic process
Over-activation of the fibrinolytic system may result in proteolytic destruction of fibrinogen. However, the effect of the degradation products formed during fibrinogenolysis on fibrinolytic process and plasminogen/plasm...
Development and validation of a capillary electrophoresis method for determination of oxcarbazepine and zonisamide in pharmaceuticals
A simple, rapid capillary electrophoretic (CE) method has been evaluated and validated for determination of two newer antiepileptic drugs: oxcarbazepine and zonisamide, as pure substances and in tablet form. The method...
Differential diagnosis between fibromyalgia syndrome and myofascial pain syndrome
[b]Introduction[/b]. Fibromyalgia syndrome (FMS) and myofascial pain syndrome (MFPS) can be ranked among disease entities being difficult to diagnose clinically, manifesting themselves mainly through pain in specific hyp...
Combination therapy of basal-cell carcinoma in 31-year-old patient with nevoid basal cell carcinoma syndrome – Case study
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disease that is manifested in a number of disorders concerning the skin, skeleton, cardiovascular and nervous systems. Various defects which can be observed...
Metallothionein and manganese concentrations in brain tumors
Metallothioneins (MT) take part in the homeostasis of the metals which are necessary for the proper metabolism and they also take part in the detoxication of toxic metals from the tissues. They also protect the tissue fr...