The Role Of Hypercholesterolemia In Idiopathic Carpal Tunnel Syndrome
Journal Title: Journal of Neurological Sciences-Turkish - Year 2007, Vol 24, Issue 1
Abstract
A past study has demonstrated that hypercholesterolemia may increase intraneural connective tissue proliferation of the median nerve and may alone be an independent risk factor for idiopathic carpal tunnel syndrome (CTS) development. This study aims to evaluate lipid profile in CTS patients classified as ‘idiopathic’ in our clinic. Anamnesis clinical findings referred to the neurology clinic and patients finally diagnosed with CTS by electrophysiological examinations have been retrospectively studied. 73 idiopathically classified patients with sufficient data and 50 health persons in similar age range with these patients were taken as control group. First, patient and control groups are compared with regards to serum triglyceride (TG), total cholesterol (TC), LDL-cholesterol, and HDL-cholesterol levels. Then, patients with CTS were divided into 2 groups, being mild and moderate-severe, based on electrophysiological criteria defined by Padua et al. The two groups were compared with regards to lipid profile both in themselves and with the control group. In idiopathic CTS patients, TC and LDL-cholesterol level was meaningfully high compared to the control group. However, LDL-cholesterol level was meaningfully higher in the group classified as electrophysiologically medium-severe CTS compared to the mild CTS group. Hypercholesterolemia median may cause proliferation in the connective tissue in the nerve's segment within the tunnel, directly increase nerve volume or cause proliferation in the tenosinovium of tendons passed together by median nerve in carpal tunnel and may result in CTS formation by way of increasing pressure in carpal tunnel.
Authors and Affiliations
KAPLAN
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