The role of liver microenvironment cells in colorectal cancer liver metastasis
Journal Title: Journal of Surgery : Concepts & Practice - Year 2024, Vol 29, Issue 2
Abstract
The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction between cells, which jointly regulate the tumor microenvironment and play significant role in the occurrence and development of CRC liver metastasis. Consequently, a thorough investigation of the molecular mechanisms underlying CRC liver metastasis is imperative for comprehension of tumor progression, prediction of metastasis risk, and the development of innovative therapeutic strategy. This paper delved into the cellular constituents of the liver tumor microenvironment, elucidating the roles and influences of diverse cell types in the process of CRC liver metastasis, offering fresh insights and strategies for the diagnosis and management of CRC liver metastasis.
Authors and Affiliations
Yiming ZHAO, Zong WU, Lu WANG
Keywords
Related Articles
- EP ID EP750951
- DOI 10.16139/j.1007-9610.2024.02.06
- Views 26
- Downloads 1
Screening and identification of the beneficiaries of adjuvant chemotherapy based on the prognostic model of intrahepatic cholangiocarcinoma
[Objective] To establish and validate a Nomogram model for predicting the overall survival (OS) of the patients with intrahepatic cholangiocarcinoma (ICC) based on domestic multicenter data, and screen the beneficiaries...
Advances of protein lysine methyltransferases in thyroid carcinoma
Protein lysine methyltransferases (PKMT) catalyze methylation of lysine residues on histone tails and non-histone targets. These important post-translational modifications affect the structure and compactness of chromati...
Preliminary evaluation of surgical treatment for postpartum diastasis recti
Objective To evaluate the clinical efficacy, safety and the postoperative functional improvement of the surgical treatment for postpartum diastasis recti (PDR). Methods A retrospective study was conducted on the patients...
Innovative direction in minimally invasive colorectal surgery platforms and techniques and quality control
The advancements in colorectal minimally invasive surgical techniques represent not merely technological innovation but also a significant leap in surgical philosophy. Over the past half-century, we have witnessed the hi...
Emerging developments in immune checkpoint inhibitor therapy for gastroenteropancreatic neuroendocrine neoplasm
Immunotherapies targeting immune checkpoints have undergone rapid evolution, and have been preliminary explored in treatment of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) in recent years. However, their pot...