The role of microglia in the progression of glaucomatous neurodegeneration- a review
Journal Title: International Journal of Ophthalmology - Year 2018, Vol 11, Issue 1
Abstract
Glaucoma is a serious leading cause of irreversible blindness worldwide. Reducing intraocular pressure (IOP) does not always stop glaucomatous neurodegeneration and the optic nerve may continue to be damaged in the normal IOP. Microglial activity has been recognized to play essential roles in pathogenesis of the central nervous system (CNS) as well as retinal ganglion cell (RGC) survival. The relationship between the neurodegeneration and the microglia cells in glaucoma is very complicated and still remains unclear. In the present review, we summarize the recent studies of mechanisms of microglia in glaucoma neurodegeneration, which might provide new ways to treat glaucoma.
Authors and Affiliations
Jing-Ming Shi
Keywords
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- EP ID EP497789
- DOI 10.18240/ijo.2018.01.22
- Views 60
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