The safety evaluation of ethanol extract of torbangun leaves (Coleus amboinicus Lour.) on mouse fetal development
Journal Title: Jurnal Gizi dan Pangan - Year 2018, Vol 13, Issue 1
Abstract
The purpose of this study was to evaluate the safety of ethanol extract from torbangun leaves on mouse fetal development. This research used 24 female pregnant mouse. The leaves extract was administered orally at dose level of 0; 0.56; 1.68 and 3.36 g/kg body weight. The extract was given from the first day until the eighteenth day of pregnancy period. The ethanol extract of Torbangun leaves contains flavonoids, saponins, tannins, and steroids. The result showed that consumption of 3.36 g/kg torbangun leaves extract had led to significant differences in the decrease of maternal weight change, number of live fetuses, fetal weight, and fetal length. Consumption of Torbangun leaves extract during pregnancy should be avoided due to its potency to interfere the fetal development.
Authors and Affiliations
Elma Alfiah,Muhammad Rizal Martua Damanik,Katrin Roosita,Mokhamad Fahrudin,
Keywords
Related Articles
- EP ID EP721649
- DOI https://doi.org/10.25182/jgp.2018.13.1.27-32
- Views 39
- Downloads 0
Probability Method for Analyzing the Prevalence of Calcium, Iron, Zinc, and Vitamin D Deficiencies among Indonesian Adolescents
The objective of this study was to analyse the prevalence of Ca, Fe, Zn, and vitamin D deficiency (micronutrient deficiency-MD) in adolescents using probability method (PBM) and cut-off point method (CPM). This study uti...
Development of Cream Soup Made From Combination of Black Soybean (Glycine soja L. merrit) and Red Rice (Oryza nivara) as an Alternative Functional Food for Menopausal Women
This study aimed to develop an organoleptic acceptable cream soup formula made from combination of black soybean (Glycine soja L. merrit) and red rice (Oryza nivara) which met the nutritional requirements and contained a...
The Impact of Dehydration in the Third Trimesters on Pregnancy Outcome-Infant Birth Weight and Length
This cohort study aimed to analyze the effect of dehydration on pregnancy outcome. A total of 66 pregnant women aged (18-35 years) at second trimester (>12 weeks) of pregnancy was recruited from seven health centers (...
Development of High Antioxidant Red Palm Oil Cake as a Potential Functional Food
This study aimed to develop high antioxidant cake product with red palm oil (RPO) content to substitute the use of margarine as a potential functional food. This study used a complete randomized design with four levels o...
Hydration status and liver function of young men before and after Ramadan fasting
The objective of this study was to identify and analyse the hydration status and liver function of young men before and during Ramadan fasting (RF). The study design was a prospective cohort into 1st period (one week bef...