The study of biopharmaceutical and adhesive characteristics of a dental gel
Journal Title: Вісник фармації - Year 2018, Vol 93, Issue 1
Abstract
Significant prevalence of dental pathologies among different age groups of the population of Ukraine dictates the need to find new effective medicines used in the treatment of oral cavity diseases. The choice of a dosage form and the optimal composition of the active pharmaceutical ingredients introduced in it to provide the necessary therapeutic effect is of importance in the treatment of periodontal diseases. For local treatment in dentistry gels are widely used; due to formation of aqueous internal structures they can include various chemotherapeutic substances in their composition, which makes it possible to obtain a dosage form with the multi-profile action. Considering the above, the research on developing the composition and technology of the dental gel with “Phytodent” tincture (PJSC “CPP Red Star”, Ukraine), choline salicylate 80 % (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy) has been conducted. Aim. To select the optimal gel base from the solutions of polymers of the semi-synthetic and synthetic origin tested in different concentrations by studying the biopharmaceutical and adhesion characteristics of six samples of gels. Materials and methods. The biopharmaceutical studies were performed by the method of direct diffusion in 2 % agar gel containing iron (III) chloride solution as an indicator. The degree of bioavailability of the amount of active substances from gels was determined by the diameter of the colored zone. The adhesive ability was studied using an electronic dynamometer. Results and discussion. It has been found that addition of mucosal adhesives to a gel-former provides the prolonged action to gels and increases their adhesion ability. Conclusions. The results of the biopharmaceutical studies have not been allowed determining the statistically reliable advantage of any of the gel samples. Based on the results of their adhesion ability the gel compositions with the best adhesion characteristics have been found; they can be recommended for further screening studies on creation of a new dental gel.
Authors and Affiliations
Ju. S. Masliy, O. A. Ruban
Keywords
Related Articles
- EP ID EP662476
- DOI 10.24959/nphj.18.2188
- Views 135
- Downloads 0
The analysis of serotonin derivatives from safflower seeds
Safflower, or American saffron, or wild saffron, or thistle (Carthamus tinctorius L.) is found both in the wild form as a weed and in the cultivated form. About 200 chemical components have been isolated from various org...
Дослідження сапонінів спиртового екстракту зі жмиху плодів малини звичайної методом ВЕРХ
Мета. Метою даної роботи стало дослідження сапонінів етанольного екстракту зі жмиху плодів малини звичайної.Матеріали та методи. Об’єктом дослідження був екстракт, отриманий зі жмиху плодів R. Idaeus. Дослідження сапонін...
Клініко-економічний аналіз фармакотерапії пацієнтів з хронічним панкреатитом у закладі охорони здоров’я м. Дружківки
Мета роботи – визначення відповідності фармакотерапії пацієнтів з хронічним панкреатитом (ХП) медико-технологічним документам за допомогою клініко-економічного аналізу. Матеріали та методи. Проаналізовано 94 історії хвор...
Development of the methods for the quantitative determination of fusidic acid and panthenol in the composition of “Fuzipam-derma” dermatological gel
Aim. To develop and validate the methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel. Materials and methods. The determination was performed by high performance liquid chromato...
The reactivity of ethyl esters of 2-(benzoylamino)(1-R-2-oxoindoline-3-ylidene) acetic acids
The studies in a series of 2-(benzoylamino)(1-R-2-oxoindoline-3-ylidene) acetic acids and their derivatives have shown that compounds of the isostructural series exhibit the nootropic, antihypoxic, anabolic activity.Aim....