The therapeutic targets for psoriasis and translational medicine
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 2
Abstract
Psoriasis is an immune-mediated, chronic, inflammatory systemic disorder with a decrease on the quality of life. The interleukin-23 (IL-23)/IL-17 axis plays a crucial role in the pathogenesis of psoriasis. Im‐ mune cells and various cytokines are involved, including interferon-α (IFN-α), tumor necrosis factor-α (TNF-α), IFN-γ, IL-12, IL-22, IL-23 and IL-17. Based on elucidated pathogenesis, biologics targeting TNF-α, IL-23, and IL-17 have been approved in the treatment of psoriasis and achieved satisfying efficacy. However, it' s still far from complete cure. At present, more therapeutic targets are under research or in clinical trials, such as JAK-STAT pathway, aryl hydrocarbon receptor and Rho-associated kinase. This review summarizes therapeutic targets and biologics of psoriasis and provides a reference for the clinical transformation of promising therapeutic targets.
Authors and Affiliations
Liu Yiyuan, Man Xiaoyong
Keywords
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- EP ID EP767230
- DOI 10.12287/j.issn.2096-8965.20210208
- Views 13
- Downloads 0
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