The Use of Intravitreal Aflibercept in the Treatment of Wet Type of Age Related Macular Degeneration
Journal Title: BMH Medical Journal - Year 2015, Vol 2, Issue 2
Abstract
Aflibercept, an anti vascular endothelial growth factor (anti-VEGF) which was originally developed in the treatment of large bowel cancers, has been found to be effective in the treatment of wet type of age related macular degeneration (ARMD), a potentially sight threatening condition affecting the retina. Chemically this biological drug is C4318 H6788 N1164 O1304 S12 with a molecular weight of 96.9 KDa. This is manufactured as a lipid soluble recombinant fusion glycoprotein that binds with both forms of vascular endothelial growth factors, i.e. A and B as well as placental growth factors, thus blocking the angiogenic action and consequent neovascular membrane growth, the pathognomonic feature of wet ARMD.
Authors and Affiliations
Rejith Rag
Keywords
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