The value of measuring trace elements and oxidative/antioxidant factors in umbilical blood in predicting the onset and evaluation of neonatal respiratory distress syndrome
Journal Title: Journal of Clinical Pediatrics - Year 2025, Vol 43, Issue 3
Abstract
[Objective] To determine the trace elements and oxidative/antioxidant factors in cord blood of premature infants, and to clarify their value in predicting the onset and evaluation of neonatal respiratory distress syndrome (NRDS). [Methods] Premature infants with gestational age less than 34 weeks who were hospitalized in the neonatal department from Dec. 2022 to Dec. 2023 were selected as the subjects. The levels of trace elements were determined by flame atomic absorption spectroscopy, and the levels of oxidative factor malondialdehyde (MDA) and antioxidant factor superoxide dismutase (SOD) were measured by surface linked immunosorbent assay. The differences in the above indicators between the NRDS group and the control group were compared. The value of each indicator in predicting the onset of NRDS were determined by the receiver operative curve (ROC). [Results] The cord blood copper levels and zinc levels in the NRDS group were significantly lower than those in the control group. The SOD level in the NRDS group was lower than that in the control group, and the MDA level was higher than that in the control group. Meanwhile, the SOD/MDA ratio in the NRDS group was significantly lower than that in the control group. The area under the curve of zinc, copper, SOD, MDA, and SOD/MDA in cord blood predicting the onset of NRDS were 0.728, 0.917, 0.627, 0.780, and 0.824, respectively. [Conclusions] The decrease in levels of trace elements copper and zinc in cord blood and the imbalance of oxidative/antioxidant factors are involved in the pathogenesis of neonatal respiratory distress syndrome.
Authors and Affiliations
Jing HUANG, Xiaochen LIU, Xiong GAO, Xiaowen LI, Guanghong LI, Luquan LI
Keywords
Related Articles
- EP ID EP763264
- DOI 10.12372/jcp.2025.24e0424
- Views 16
- Downloads 0
Research progress on application of palliative care in pediatric patients with cancer
Palliative care, as an effective method to improve the quality of life of cancer patients and their families, is still in the ice-breaking stage among children and adolescent patients in China. Currently, the percentage...
Progress of intravenous thrombolysis in pediatric acute ischemic stroke
Pediatric acute ischemic stroke is a rare condition with a poor prognosis and significant recurrence rates. Intravenous tissue plasminogen activator (IV-TPA) has been proven to be an effective treatment for acute ischemi...
Analysis of factors associated with the prognosis of embryonal tumor with multilayered rosettes: a single-center retrospective study
[Objective] The purpose of this study was to retrospectively analyze the main factors affecting the prognosis of pediatric intracranial embryonal tumor with multilayered rosettes (ETMR) and to provide effective suggestio...
Analysis of risk factors for death from influenza A (H1N1)-associated encephalopathy in children
[Objective] To explore the risk factors of death from influenza A (H1N1)-associated encephalopathy (IAE) in children, and to provide evidence for early clinical diagnosis and intervention. [Methods] The clinical data of...
Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures
[Objective ] This study aimed to identify the risk factors associated with the recurrence of seizures during the acute phase of febrile seizures (FS) in children. [Methods ] A retrospective analysis of FS patients treate...