Theoretical and experimental substantiation of the composition of the gel with the anti-inflammatory and local anesthetic action for application in sports medicine
Journal Title: Фармацевтичний журнал - Year 2014, Vol 2, Issue 2
Abstract
The use of compounds of the natural origin, in particular standardized substances of propolis in combination with local anesthetics in the composition of soft dosage forms results in more expressed anti-inflammatory and prolong analgesic action. The choice of the most rational active pharmaceutical ingredients (API) in the medicinal form under research is a topical problem when developing a new medicine. The aim of the work was to substantiate theoretically and experimentally the composition of the gel with the anti-inflammatory and local anesthetic action under the conditional name «ArthpromentÒ» for application in a complex treatment of mechanical injuries and post-traumatic inflammations of extremities soft tissues, diseases of the locomotor apparatus, musculoskeletal injuries that are characteristic for sports medicine and sports during the rehabilitation period such as bruises, dislocations, sprains, ruptures of ligaments, tendons, etc. The object of the research was the model samples of the gel bases with different concentration of the main API included in the composition of the medicine developed. The methods of analysis of modern literature sources data and the preclinical pharmacological studies have been used. The composition of the gel with the anti-inflammatory and local anesthetic action under the conditional name «ArthpromentÒ» has been theoretically and experimentally substantiated. Based on analysis of the data of modern literature references and the preclinical pharmacological studies conducted the rational concentration of API (propolis phenolic hydrophobic drug – 3%, articaine hydrochloride – 5%, menthol and rosemary oil – 1%) in the composition of the gel developed has been determined. It has been proven that the composition proposed contain the complex of biologically active substances in API of the natural and synthetic origin, their totality is adequate to the complex pathogenesis of this pathology, and the use of the active substances in the given combination and the given concentration synergistically impact on the complex pharmacological effect of the medicine developed.
Authors and Affiliations
O. S. Shpychak, O. I. Tikhonov
Keywords
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