Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 2
Abstract
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with longterm damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The present study was carried out to investigate the effects of garlic (Allium sativum Linn) juice on biochemical parameters, enzyme activities and lipid peroxidation in alloxan-induced diabetic rats. Alloxan was administered as a single dose (150mg/kgBW) to induce diabetes. A dose of 1ml of garlic juice/100g body weight (equivalent to 0.4 g/100g BW) was orally administered daily to alloxan-diabetic rats for four weeks. The levels of glucose, urea, creatinine and bilirubin were significantly (p < 0.05) increased in plasma of alloxan-diabetic rats compared to the control group. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline and acid phosphatases (AlP, AcP) activities were significantly (p < 0.05) increased in plasma and testes of alloxan-diabetic rats, while these activities were decreased in liver compared with the control group. Brain LDH was significantly (p < 0.05) increased. The concentration of thiobarbituric acid reactive substances and the activity of glutathione S-transferase in plasma, liver, testes, brain, and kidney were increased in alloxan diabetic rats. Treatment of the diabetic rats with repeated doses of garlic juice could restore the changes of the above parameters to their normal levels. The current results showed that garlic juice exerted antioxidant and antihyperglycemic effects and consequently may alleviate liver and renal damage caused by alloxan-induced diabetes.
Authors and Affiliations
El-Khedr Mohamed Mostafa El-Gamal
Keywords
Related Articles
- EP ID EP274094
- DOI -
- Views 86
- Downloads 0
Therapy concept for Surgical Uprighting of the Impacted Second Mandibular Molar
Impaction of permanent teeth is a relatively common occurrence and can involve any tooth in the dental arch. Impacted mandibular second molars are less frequently encountered, but when they occur they may present a chall...
The Influence of Number of Signal Average Variation to the Scan Time and Anatomic Information of Lumbar MRI on Sagittal Slice with Stir Sequence
Background: The number of signal averages (NSA) parameters is one of the parameters that can affect the quality of the MRI image making the selection of accurate parameters is necessary to produce an optimal image produc...
An Audit on Abdominal Trauma
Background: One of the most frequently occurring surgical emergencies is Blunt Abdominal Trauma, and has a strong association with high rates of mortality or morbidity. Being the leading cause of disability it poses a hu...
Role of Serum Amylase and Lipase Levels in the Classification of Acute Pancreatitis According to Revised Atlanta Classification
Introduction: Revised Atlanta classification proposed the use of morphologic CECT criteria to diagnose the specific type of acute pancreatitis into acute interstitial oedematous pancreatitis (IEP) or acute necrotizing pa...
Hair Dye Poisoning with Refractory Arrthymia & Interstitial Nephritis Rare Presentation
A 45year old female with no comorbid illness brought to emergency room with alleged history of consumption of 100ml of hair dye at 10am at her residence. She was initially treated at government hospital and brought to ou...