Therapeutic Effects of Neural and Other Diverse Pluripotent Stem Cells in Treating Various Neurological Disorders
Journal Title: Annual Research & Review in Biology - Year 2015, Vol 6, Issue 6
Abstract
Stem cells are unipotent (producing only one cell type, i.e. their own), pluripotent (giving rise to all cell types making up a body), or multipotent (having the ability to develop into more than one type of cell but less than that possessed by pluripotent) cells possessing an unlimited ability to proliferate and differentiate under proper culturing conditions. They can be conveniently obtained from the inner cell mass of mammalian embryos in the blastocyst stage (ESCs, which are pluripotent) and adult tissues (ASCs, which are multipotent so far). Human embryonic stem cells (hESCs) proved to be fatal for the embryos owing to which induced pluripotent cells (iPSCs) have been developed by forcibly inducing the expression of specific regenerative genes. All types of pluripotent stem cells, which include ectodermal stem cells, mesenchymal stem cells and rare types of endodermal stemcells, are used in treating several early onset neurodevelopment diseases and late-onset neurodegenerative disorders. Neural stem cells (NSCs) can be found in the developing and adult central nervous system (CNS) and form a population comprising astrocytes, oligodendrocytes and neurones. Several researches conducted in animal models have shown structural and functional recovery as they have been researched on to treat diseases like stroke, brain tumours, metastatic tumours, human primary tumours, spinal cord injury and multiple sclerosis and, for this purpose, neural stem cells enjoy a pivotal status. Their efficacy and safety has been proven not only by the data collected from literature, but also from researches in animal models induced with various neurological disorders.
Authors and Affiliations
Aminah Suhail Qureshi, Sikander Ali
Keywords
Related Articles
- EP ID EP353406
- DOI 10.9734/ARRB/2015/10480
- Views 141
- Downloads 0
Evaluation of Inhibition of Fungal Spore Germination by Rhizospheric Bacterial Extracts
Aims: This work aims to evaluate the anti-germinative activity of bacterial extracts. These bacteria were already characterized for their antagonistic capacity in vitro against telluric phyto-pathogens fungi: Fusarium ox...
Roosting Behaviour of Black-winged Kite (Elanus caeruleus) Inhabiting the Arid Zone of Rajasthan
The word “Roost” means “a sleeping house of fowls”. The roosting ecology of Black-winged kite was studied from January 2012 to December 2014 in rural and urban areas of Churu city and rural areas of Ratangarh of Churu di...
Evaluation of Spirogyra rhizobrachialis, Merismopedia elegans and Synedra spp as Potential Sources of Proteases
Aims: To isolate and characterise the proteases from Spirogyra rhizobrachialis, Merismopedia elegans and Synedra species in order to evaluate them as potential sources of protease. Study Design: Three Algae species were...
Taxonomy of Earthworm Species Collected from East Coast of Guyana
Earthworms contribute significantly towards the proper functioning of our ecosystem and are environmentally and economically beneficial to the well-being of other organisms. These soil dwelling organisms serve to enhance...
Degradation of Phenol Containing Wastewater by Advance Catalysis System – A Review
Phenols and their derivatives are broadly distributed as a characteristic pollutant due to its frequent presence in effluents of many industrial processes. Most of the phenolic compounds are toxic to living organisms as...