Therapy Potential of Tailless Bacteriophage ΦHN161 and its Ability in Modulating Inflammation Caused by Bacterial Disease

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Therapy Potential of Tailless Bacteriophage ΦHN161 and its Ability in Modulating Inflammation Caused by Bacterial Disease

Journal Title: Veterinary Medicine – Open Journal - Year 2016, Vol 1, Issue 2

Abstract

Almost all the phages reported were long-tail or short-tail, belong to the Myoviridae or Podoviridae phage families, little information was available on tailless bacteriophages and their biological significance in therapy. Tailless bacteriophage φHN161 in this study was isolated from sewage water samples. This representative phage displayed a strong ability in eliminating pathogenic Escherichia coli O161. Mice challenged with E. coli O161 were treated with different doses of phage φHN161 for comparing sterilization rate and immunological reaction with those untreated mice in control group. Phage of higher dose was much more effective than of lower dose in eliminating host cells both in vitro and in vivo, while a lower dose of phage treatment could drastically reduce inflammation caused by E. coli O161 infection. Altogether, these observations expanded the diversity of phages that could be utilized as antimicrobial agents substitute in animals; these findings also reminded people to pay attention to the dosage of bacteriophages used in therapy.

Authors and Affiliations

Qigai He

Keywords

Escherichia coli. Bacteriophage φHN161. Inflammatory cytokine.

EP ID EP545693
DOI 10.17140/VMOJ-1-107
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