Thyroid Function Abnormalities in Patients with Chronic Kidney Disease - A Prospective Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 4
Abstract
Introduction: The kidney normally plays an important role in the metabolism, degradation, and excretion of several thyroid hormones (THs). It is not surprising therefore that impairment in kidney function leads to disturbed thyroid physiology. All levels of the hypothalamic-pituitary-thyroid axis may be involved, including alterations in hormone production, distribution, and excretion. Aim: The aim of this study is to study the correlation between TH dysfunction and severity of renal diseases and to differentiate primary thyroid diseases from thyroid dysfunction due to chronic renal failure. Materials and Methods: Patients with chronic renal failure who are on conservative management were included in the study. Thyroid profile would be done in all patients who fulfill the inclusion criteria. Results: Excluding patients with hypothyroidism, T3 level is low in 46% of the patients, and T4 level is low in 20% of the patients. Excluding 5 hypothyroidism patients who have low T4 values, 9 (21.33%) other patients had T4 level below normal and low T3 syndrome. Number of patients with low T4 does not correlate with severity of renal disease. Conclusion: Chronic kidney disease leads to significant changes in the TH levels, which need to be interpreted carefully in these patients.
Authors and Affiliations
Aarathy Kannan, V Sriramakrishnan, B Kannan, Heber Anandan
Keywords
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