Thyroid Status in Non-Pregnant & Pregnant Women
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. Thyroid hormones have important role in embryogenesis and fetal development during pregnancy. Therefore, thyroid status is frequently assessed during pregnancy, both to evaluate suspected thyroid abnormalities, and to monitor the status of pre-existing thyroid disease. The aim and objective of the study was to compare thyroid function test in each trimester in normal pregnant women with non pregnant women. A case-control study containing two groups of women,75 normal pregnant women as cases selected from the first trimester (25 samples), the second trimester (25 samples), and the third (25 samples) trimester and 75 randomly selected non-pregnant healthy female controls. Thyroid function tests were carried out by measuring the serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT4, T4), and free and total triiodothyronine (FT3, T3) by commercially available radio-immunoassay kit. The statistical significance was evaluated by Student’s t-test. p value <0.05 was the level of statistically significance. In the third trimester, the mean TT4 increased significantly than the mean of non-pregnant women. The mean TT3 levels of pregnant women was increased in the second trimesters, and declined in the third trimester than the mean of non-pregnant women. In the third trimester, the mean FT4 significantly decreased than the mean for non-pregnant women. Mean FT3 values showed declining over the trimesters relative to the non-pregnant control group that were significant in second and third trimesters. In each trimester, the mean TSH levels of pregnant women were lower than the mean level of non-pregnant but were not statistically significant in second and third trimesters. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals in order to avoid mis-interpretation of thyroid function during pregnancy. Keywords: Pregnancy, Thyroid stimulating hormone (TSH), Free thyroxine (FT4), Total thyroxin (T4), Free triiodothyronine (FT3), Total triiodothyronine (T3).
Authors and Affiliations
Manjunatha S, Basavraja G N, Veena H C, Ramesh S Patil
Keywords
Related Articles
- EP ID EP378510
- DOI -
- Views 77
- Downloads 0
Evaluation of Predictive Value of Pre-treatment Inflammation Based Prognostic Biomarkers for Detection of Invasiveness of Bladder Carcinoma in a Tertiary Care Centre of West Bengal
The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are pretreatment inflammation based prognostic biomarkers used to predict oncologic outcomes in urologi...
To Study the Blood Pressure Response to Benidipine in Hypertension Patients
Abstract: Hypertension is most important cause for morbidity and mortality worldwide, most of the hypertension patients are not aware of disease and most of them are not under control.To study the clinical features, of H...
Etiology and clinico-social profile of chronic kidney disease cases admitted to a dialysis unit in a rural tertiary care hospital
Abstract: Chronic kidney disease is an emerging public health global problem, and the incidence as well as prevalence of the disease is on the rise. Clinico-social profile, etiology, associated risk factors and financial...
The Efficacy of Short Wave Diathermy (SWD) in Decreasing the Cost Effect & Time in Treatment of Osteoarthritis (OA) Knee
Osteoarthritis (OA) is by far the most common form of arthritis. It is strongly associated with ageing and is a major cause of pain and disability in older people. Joint pain and stiffness are the most common symptom for...
A Study on the Effectiveness of a Self Instructional Module among Primary Care Givers to Paraplegic & Quadriplegic Patients
Abstract: Care of paralysed patients & their associated needs, dependence, supporting care on the primary care givers as real challenges. So, the need of the hour is to provide comprehensive care to the survivors. This c...