Tip 2 Diyabetiklerde Lökositlerde Oksijen Bağımlı Antimikrobiyal Aktivitenin Tayini
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2009, Vol 13, Issue 2
Abstract
Amaç: Bu çalışmada tip 2 diyabetik hastalarda lökositlerde oksijen bağımlı baktesididal aktivitenin etkilenip etkilenmediğini araştırdık. Gereç ve Yöntemler: Çalışmaya 28 diyabetik hasta ve demografik açıdan benzer 31 normal birey alınmıştır. Çalışmaya alınan bireylerden alınan kan örneklerinden lökositler ayrıştırılmış ve oksijen bağımlı antimikrobiyal aktivitede rol oynayan enzimlerden superoxide dismutaz (SOD), glutathione reduktaz (GSH-R), gluthatione peroxidaz (GSH-Px), katalaz ile lipid peroxidation ürünü olarak, thiobarbiturik asid reaktive substans (TBARS) ölçülmüştür. Bulgular: Tip 2 diyabetiklerde lökositlerde SOD, GSH-R, and katalaz aktiviteleri kontrol grubundan farksız bulunmuştur (p>0.05). GSH-Px düzeyleri ise diyabetiklerde kontrol grubuna göre daha düşük bulunmuştur (0.012±0.08 U/mg.pr'e karşı 0.057±0.046 U/mg.pr, p<0.05). TBARS düzeyleri ise diyabetik grupta kontrol grubundan farksız bulunmuştur (5.49±1.31 mmol/l karşı 5.53±1.45 mmol/l, p=0.905). Sonuç: Diyabetik bireylerin bilinen bazı enfeksiyonlara karşı yatkın olmasının lökositlerdeki oksijen bağımlı bakterisidal aktivite ile ilişkili olduğunu söylemek zordur. Türk Jem 2009; 13: 20-4
Authors and Affiliations
Mustafa Kanat, Orkide Donma, Cem Aygün, Emine Sardoğan, Özlem Ekmekçi, Murat Sipahioğlu, Reşat Özaras
Keywords
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