To Evaluate the Anxiolytic Effect of Diltiazem in Albino Rats by Elevated-Plus Maze Model.
Journal Title: IJAR-Indian Journal of Applied Research - Year 2017, Vol 7, Issue 2
Abstract
Diltiazem, a Calcium channel antagonist (CCA), is widely used in treatment of variety of cardio-vascular disorders for their actions on the Voltage Sensitive Calcium Channels (VSCC) in cardiac and smooth muscles. As some patients with ischemic heart disease (IHD) have an anxiety state apart from chest pain and diltiazem is a known CCA prescribed for IHD patients, the present study is taken up to evaluate anxiolytic action of diltiazem in albino rats in elevated plus maze model, an experimental model of anxiety. Diltiazem is evaluated for anxiolytic effect in graded doses of 5mg/kg, 10mg/kg & 20mg/kg body wt i.p. (intraperitoneal) and their effects are compared with standard drug Diazepam. The test drug diltiazem produced significant anxiolytic effect at doses of 10mg/kg & 20mg/kg body wt i.p treatment. Further, low dose combination of Diltiazem 5 mg/kg body wt + Diazepam 1 mg/kg body wt i.p. treatment showed potentiation of anxiolytic effect in elevated plus maze model.
Authors and Affiliations
Dr. Dattatraya. K. Joshi, Mr. P. Durga Prasad, Dr. Bheemesh Naidu Mattam
Keywords
Related Articles
- EP ID EP461726
- DOI -
- Views 69
- Downloads 0
Role of Digital Media as Information Resource Among First Year Medical Graduates of Nagpur
Background- The academic landscape in medical education sector has been comprehensively transformed by the recent advances in digital media & information technology. With availability of these online resources students c...
PROBLEMS FACED BY GERIATRIC PEOPLE
The geriatric population has increased dramatically during the past 100 years. If the current trend continues, the number of persons aged 65 or older will more than double during the next 30 years. As a result, we need t...
A SPOT URINE PROTEIN CREATINE RATIO IS AN ALTERNATIVE TO 24 HOURS URINARY PROTEIN FOR DETECTION OF PIH AND ITS SEVERITY.
Protein/creatinine ratio of a single voided urine specimen may have a role in the management of ambulatory women with suspected PIH, which necessitates further research in the field....
Glomus Tumor on Dorsum of Foot: A Rare Occurrence
Glomus tumor, also known as Glomangioma, originates in the neuromyoarterial glomus, a normal arteriovenous shunt abundantly supplied with nerve fibres and fulfilling a temperature-regulating function. The classic locatio...
A STUDY OF OUTCOME OF TYMPANOPLASTY ASSCESSED BY AUDIOGRAM IN TERTIARY CARE HOSPITALS IN SOUTH INDIA
Tympanoplasty is a surgical technique to repair defect in tympanic membrane with placement of graft. The goal of surgical procedure is not only to close the perforation but also improve the hearing.In this study our aim...