To evaluate the in vitro transcorneal penetration of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin in the presence and absence of amniotic membrane using goat cornea
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2017, Vol 3, Issue 2
Abstract
Abstract This study was intended to evaluate the in vitro transcorneal penetration of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin in the presence and absence of amniotic membrane using goat cornea. This was an experimental study to estimate transcorneal penetration of four 0.3% fluoroquinolone formulations. In the absence of amniotic membrane, the calculated flux of the transfer in case of ofloxaxcin, pefloxacin, lomefloxacin and sparfloxacin 0.3% were found to be 2.41µg/cm2/hr, 4.45 µg/cm2/hr, 7.4 µg/cm2/hr and 0.968 µg/cm2/hr respectively. In the presence of amniotic membrane these values changed to 3.38 µg/cm2/hr, 2.15µg/cm2/hr, 5.75 µg/cm2/hr and 2.4 µg/cm2/hr respectively. The transcorneal permeation studies using goat cornea showed the cumulative release in the following order as lomefloxacin>pefloxacin>ofloxacin>sparfloxacin.
Authors and Affiliations
Alok Kumar Ravi, Nihar Ranjan Biswas, Thirumurthy Velepandian, Raju Sampangi, Sat Pal Garg, Supriyo Ghose
Keywords
Related Articles
- EP ID EP288672
- DOI -
- Views 69
- Downloads 0
Pulmonary silicotuberculosis in a stone miner
Abstract We are presenting a case of a patient a former stone miner, male, 45 years old, who developed silicosis after almost a decade of occupational exposure to silica dust in stone mining industry. He was detected...
MANAGEMENT OF EMPYEMA THORACIS IN PEDIATRIC POPULATION – A TERTIARY CENTRE EXPERIENCE
Abstract Background: Significant morbidity is often observed in inadequately managed Empyema cases. Aims and Objectives: To evaluate the different treatment modalities in the management of Paediatric Empyema Thoracis. M...
CT Evaluation of Epileptic Patients
Abstract Introduction – Computed tomography (CT) scan is the technique of choice for the investigation of patients with seizure and epilepsy (specially in resource poor state). CT scan of brain is particularly helpful f...
Delayed presentation of H-type rectourethral fistula in male
ABSTRACT : H-type anorectal malformaon characterized by a fistulous communicaon between urethra and rectum with patency of both epithelial tracts is a rare abnormality in male children. We recently managed a 15-year old...
A Rare presentation of Pulmonary Tuberculosis with Polyarthralgia: Poncet’s Disease
Tuberculosis is a major public health concern. Delayed diagnosis and low index of suspicion are the main reason why the incidence of TB remain high.[1] Reactive arthritis and erythema are uncommon presentation of tubercu...