To study association of trp 53 arg 72 pro polymorphic variant with breast cancer-a case control study in north Indian population
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 8
Abstract
Objectives: The single nucleotide polymorphism (SNP) at Trp53arg72 pro genotypes is found to be associated with breast cancer, with variable results, the aim of this study is to evaluate the frequency of SNP at Trp 53 codon 72 and its association with breast cancer in north Indian population. Methods: 30 patients with breast cancer were compared with 30 controls. Genotype and allele distribution of Trp53 codon 72 where determined using polymerase chain reaction- restriction fragment length polymorphism method. Results: The genotypic distribution of arg/arg, arg/pro, pro/pro among cancer patients vs controls were 53.33%, 33.33%, 13.33% and 56.7%, 26.7%, 16.7% respectively (p=0.83). Conclusion: though the difference in genotypic distribution was not significant, we found in the higher number of heterozygous genotypes (arg/pro) in cancer tissue suggesting, heterozygous (arg/pro) genotype may predispose women to breast cancer. This necessitates conducting the study including more patients.
Authors and Affiliations
Pankaj Kumar Kannaujiya
Keywords
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