TO STUDY IMPACT OF BLOOD COMPONENT TRANSFUSION THERAPY IN ACUTE FEBRILE ILLNESS PATIENTS IN INTENSIVE CARE UNIT
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 39
Abstract
BACKGROUND Acute Febrile Illness in an individual is defined as a fever of 38.3⁰C or more for at least 2 days or fever with no localising causes like pneumonia or diarrhoea (for the present study). Malaria, leptospirosis, dengue, typhoid fever and certain unidentified viral fevers are the usual causes in monsoon. The present study is planned to gain insight into the most common types of coagulation abnormalities seen in AFI and their effect on the course of disease. MATERIALS AND METHODS A descriptive study was performed in 100 indoor patients admitted in ICU with AFI with one or more of these coagulation abnormalities: Platelet count <1,50,000/mm3, or patients with INR>1.2 or patients with PTTK prolonged by >6 seconds were included. Their clinical profile, biochemical parameters, severity of illness (SOFA Score), treatment received were correlated with outcome with Chi square test. RESULTS Out of these 100 cases, 56 were male with mean age of 26.46 years and 44 were female with mean age of 25.5 years, indicating that tropical diseases are more common in the working age group. Most of the patients suffered from Malaria (53), Leptospirosis (13), Dengue (7) in decreasing order whereas 27 had unidentified aetiology. Thrombocytopenia (100 %), and prolonged bleeding time followed by INR (59%) were most common deranged parameters. Mortality rates were high with patients having thrombocytopenia. (p=0.0281). Patients in ICU were studied according to SOFA Score mean (11.268) in survived and (>15) in expired patients. CONCLUSION 1. The commonest coagulation abnormality in patients with AFI is Thrombocytopenia seen in almost all patients followed by raised INR (57), Prolonged PTTK (27), reduced serum fibrinogen levels. 2. Severe thrombocytopenia, raised INR, prolonged PTTK, reduced serum fibrinogen levels are poor prognostic markers of outcome in AFI patients. 3. Blood component therapy improved outcome in patients (90%) who had clinically evident bleeding in presence of deranged coagulation parameters.
Authors and Affiliations
Hedau Mayur Ramkrishnarao, Nagar Vidya Sanjay
Keywords
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- EP ID EP213172
- DOI 10.14260/Jemds/2017/681
- Views 89
- Downloads 0
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