Tofacitinib- A First-In-Class Drug for Rheumatoid Arthritis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic and disabling autoimmune inflammatory disease characterized by inflammation of the synovial lining of the joints, tendons and periarticular structure affecting approximately 1% of the population world-wide. Tofacitinib is a novel oral Janus-kinase inhibitor approved for the treatment of RA patients as a second line therapy in those who fail to respond to methotrexate therapy. Clinical trials with tofacitinib have shown reasonable efficacy. However, the drug’s greatest limitation is its potential to induce cancers and latent infections could be reactivated. Nevertheless, the drug can slow the progression of the disease and has evoked lot of interest due to the fact that it is a first in class molecule for the treatment of rheumatoid arthritis.
Authors and Affiliations
Sujithera Haridoss, Melvin George, Damal Kandadai Sriram
Keywords
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